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Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...

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Detalles Bibliográficos
Autores principales:	Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415968/ https://www.ncbi.nlm.nih.gov/pubmed/28624200 http://dx.doi.org/10.1016/j.omtn.2017.04.003

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