RENAL ISCHEMIA REPERFUSION CAUSES BRAIN HIPPOCAMPUS OXIDATIVE DAMAGE AND INHIBITION EFFECT

BACKGROUND: The acute kidney injury (AKI) may do damage to remote organs. Objective of the study is to investigate effect of seaweed extract (SE) on brain oxidative damage in kidney ischemia/reperfusion rats. MATERIAL AND METHODS: Animals were randomly divided into five groups. SE pre-fed to rats. R...

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Detalles Bibliográficos
Autores principales: Yu, Fang, Liang, Haidong, Xin, Shimeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416646/
https://www.ncbi.nlm.nih.gov/pubmed/28487895
http://dx.doi.org/10.21010/ajtcam.v13i5.9
Descripción
Sumario:BACKGROUND: The acute kidney injury (AKI) may do damage to remote organs. Objective of the study is to investigate effect of seaweed extract (SE) on brain oxidative damage in kidney ischemia/reperfusion rats. MATERIAL AND METHODS: Animals were randomly divided into five groups. SE pre-fed to rats. RESULTS: Kidney I/R may cause oxidative injury in kidneys and brains tissue in rats. SE pre-treatment can decrease lipid peroxidation levels and increase antioxidant enzymes activities in kidney and brain hippocampus of kidney I/R rats. CONCLUSION: Our results indicate that SE is useful for brain nerve function keeping in kidney I/R rats.

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