Effects of bumetanide on neurobehavioral function in children and adolescents with autism spectrum disorders

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In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl(−))(i) levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide reduced the severity of ASD i...

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Detalles Bibliográficos
Autores principales: Lemonnier, E, Villeneuve, N, Sonie, S, Serret, S, Rosier, A, Roue, M, Brosset, P, Viellard, M, Bernoux, D, Rondeau, S, Thummler, S, Ravel, D, Ben-Ari, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416661/
https://www.ncbi.nlm.nih.gov/pubmed/28291262
http://dx.doi.org/10.1038/tp.2017.10

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