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Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression

Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patient...

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Autores principales: Alves, N D, Correia, J S, Patrício, P, Mateus-Pinheiro, A, Machado-Santos, A R, Loureiro-Campos, E, Morais, M, Bessa, J M, Sousa, N, Pinto, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416672/
https://www.ncbi.nlm.nih.gov/pubmed/28291258
http://dx.doi.org/10.1038/tp.2017.29
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author Alves, N D
Correia, J S
Patrício, P
Mateus-Pinheiro, A
Machado-Santos, A R
Loureiro-Campos, E
Morais, M
Bessa, J M
Sousa, N
Pinto, L
author_facet Alves, N D
Correia, J S
Patrício, P
Mateus-Pinheiro, A
Machado-Santos, A R
Loureiro-Campos, E
Morais, M
Bessa, J M
Sousa, N
Pinto, L
author_sort Alves, N D
collection PubMed
description Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression. Through re-exposure to an unpredictable chronic mild stress protocol in rats, we observed the re-appearance of emotional and cognitive deficits. Furthermore, treatment with the antidepressants fluoxetine and imipramine was effective to promote sustained reversion of a depressive-like phenotype; however, their differential impact on adult hippocampal neuroplasticity triggered a distinct response to stress re-exposure: while imipramine re-established hippocampal neurogenesis and neuronal dendritic arborization contributing to resilience to recurrent depressive-like behavior, stress re-exposure in fluoxetine-treated animals resulted in an overproduction of adult-born neurons along with neuronal atrophy of granule neurons, accounting for an increased susceptibility to recurrent behavioral changes typical of depression. Strikingly, cell proliferation arrest compromised the behavior resilience induced by imipramine and buffered the susceptibility to recurrent behavioral changes promoted by fluoxetine. This study shows that previous exposure to a depressive-like episode impacts on the behavioral and neuroanatomical changes triggered by subsequent re-exposure to similar experimental conditions and reveals that the proper control of adult hippocampal neuroplasticity triggered by antidepressants is essential to counteract recurrent depressive-like episodes.
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spelling pubmed-54166722017-05-12 Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression Alves, N D Correia, J S Patrício, P Mateus-Pinheiro, A Machado-Santos, A R Loureiro-Campos, E Morais, M Bessa, J M Sousa, N Pinto, L Transl Psychiatry Original Article Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression. Through re-exposure to an unpredictable chronic mild stress protocol in rats, we observed the re-appearance of emotional and cognitive deficits. Furthermore, treatment with the antidepressants fluoxetine and imipramine was effective to promote sustained reversion of a depressive-like phenotype; however, their differential impact on adult hippocampal neuroplasticity triggered a distinct response to stress re-exposure: while imipramine re-established hippocampal neurogenesis and neuronal dendritic arborization contributing to resilience to recurrent depressive-like behavior, stress re-exposure in fluoxetine-treated animals resulted in an overproduction of adult-born neurons along with neuronal atrophy of granule neurons, accounting for an increased susceptibility to recurrent behavioral changes typical of depression. Strikingly, cell proliferation arrest compromised the behavior resilience induced by imipramine and buffered the susceptibility to recurrent behavioral changes promoted by fluoxetine. This study shows that previous exposure to a depressive-like episode impacts on the behavioral and neuroanatomical changes triggered by subsequent re-exposure to similar experimental conditions and reveals that the proper control of adult hippocampal neuroplasticity triggered by antidepressants is essential to counteract recurrent depressive-like episodes. Nature Publishing Group 2017-03 2017-03-14 /pmc/articles/PMC5416672/ /pubmed/28291258 http://dx.doi.org/10.1038/tp.2017.29 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Alves, N D
Correia, J S
Patrício, P
Mateus-Pinheiro, A
Machado-Santos, A R
Loureiro-Campos, E
Morais, M
Bessa, J M
Sousa, N
Pinto, L
Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title_full Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title_fullStr Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title_full_unstemmed Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title_short Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
title_sort adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416672/
https://www.ncbi.nlm.nih.gov/pubmed/28291258
http://dx.doi.org/10.1038/tp.2017.29
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