Cargando…

Instability of default mode network connectivity in major depression: a two-sample confirmation study

Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations i...

Descripción completa

Detalles Bibliográficos
Autores principales: Wise, T, Marwood, L, Perkins, A M, Herane-Vives, A, Joules, R, Lythgoe, D J, Luh, W-M, Williams, S C R, Young, A H, Cleare, A J, Arnone, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416685/
https://www.ncbi.nlm.nih.gov/pubmed/28440813
http://dx.doi.org/10.1038/tp.2017.40
_version_ 1783233798139281408
author Wise, T
Marwood, L
Perkins, A M
Herane-Vives, A
Joules, R
Lythgoe, D J
Luh, W-M
Williams, S C R
Young, A H
Cleare, A J
Arnone, D
author_facet Wise, T
Marwood, L
Perkins, A M
Herane-Vives, A
Joules, R
Lythgoe, D J
Luh, W-M
Williams, S C R
Young, A H
Cleare, A J
Arnone, D
author_sort Wise, T
collection PubMed
description Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in connectivity strength over time in major depression. We assessed stability of connectivity in major depression between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), key nodes in the DMN that are implicated in ruminative cognitions. Functional connectivity stability between the mPFC and PCC over the course of a resting-state functional magnetic resonance imaging (fMRI) scan was compared between medication-free patients with major depression and healthy controls matched for age, sex and handedness. We tested replicability of the results in an independent sample using multi-echo resting-state fMRI. The primary sample included 20 patients and 19 controls, while the validation sample included 19 patients and 19 controls. Greater connectivity variability was detected in major depression between mPFC and PCC. This was demonstrated in both samples indicating that the results were reliable and were not influenced by the fMRI acquisition approach used. Our results demonstrate that alterations within the DMN in major depression go beyond changes in connectivity strength and extend to reduced connectivity stability within key DMN regions. Findings were robustly replicated across two independent samples. Further research is necessary to better understand the nature of these fluctuations in connectivity and their relationship to the aetiology of major depression.
format Online
Article
Text
id pubmed-5416685
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-54166852017-05-16 Instability of default mode network connectivity in major depression: a two-sample confirmation study Wise, T Marwood, L Perkins, A M Herane-Vives, A Joules, R Lythgoe, D J Luh, W-M Williams, S C R Young, A H Cleare, A J Arnone, D Transl Psychiatry Original Article Major depression is associated with altered static functional connectivity in various brain networks, particularly the default mode network (DMN). Dynamic functional connectivity is a novel tool with little application in affective disorders to date, and holds the potential to unravel fluctuations in connectivity strength over time in major depression. We assessed stability of connectivity in major depression between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), key nodes in the DMN that are implicated in ruminative cognitions. Functional connectivity stability between the mPFC and PCC over the course of a resting-state functional magnetic resonance imaging (fMRI) scan was compared between medication-free patients with major depression and healthy controls matched for age, sex and handedness. We tested replicability of the results in an independent sample using multi-echo resting-state fMRI. The primary sample included 20 patients and 19 controls, while the validation sample included 19 patients and 19 controls. Greater connectivity variability was detected in major depression between mPFC and PCC. This was demonstrated in both samples indicating that the results were reliable and were not influenced by the fMRI acquisition approach used. Our results demonstrate that alterations within the DMN in major depression go beyond changes in connectivity strength and extend to reduced connectivity stability within key DMN regions. Findings were robustly replicated across two independent samples. Further research is necessary to better understand the nature of these fluctuations in connectivity and their relationship to the aetiology of major depression. Nature Publishing Group 2017-04 2017-04-25 /pmc/articles/PMC5416685/ /pubmed/28440813 http://dx.doi.org/10.1038/tp.2017.40 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Wise, T
Marwood, L
Perkins, A M
Herane-Vives, A
Joules, R
Lythgoe, D J
Luh, W-M
Williams, S C R
Young, A H
Cleare, A J
Arnone, D
Instability of default mode network connectivity in major depression: a two-sample confirmation study
title Instability of default mode network connectivity in major depression: a two-sample confirmation study
title_full Instability of default mode network connectivity in major depression: a two-sample confirmation study
title_fullStr Instability of default mode network connectivity in major depression: a two-sample confirmation study
title_full_unstemmed Instability of default mode network connectivity in major depression: a two-sample confirmation study
title_short Instability of default mode network connectivity in major depression: a two-sample confirmation study
title_sort instability of default mode network connectivity in major depression: a two-sample confirmation study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416685/
https://www.ncbi.nlm.nih.gov/pubmed/28440813
http://dx.doi.org/10.1038/tp.2017.40
work_keys_str_mv AT wiset instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT marwoodl instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT perkinsam instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT heranevivesa instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT joulesr instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT lythgoedj instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT luhwm instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT williamsscr instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT youngah instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT cleareaj instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy
AT arnoned instabilityofdefaultmodenetworkconnectivityinmajordepressionatwosampleconfirmationstudy