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A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior

Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via...

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Autores principales: Henningsson, S, Hovey, D, Vass, K, Walum, H, Sandnabba, K, Santtila, P, Jern, P, Westberg, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416707/
https://www.ncbi.nlm.nih.gov/pubmed/28440809
http://dx.doi.org/10.1038/tp.2017.70
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author Henningsson, S
Hovey, D
Vass, K
Walum, H
Sandnabba, K
Santtila, P
Jern, P
Westberg, L
author_facet Henningsson, S
Hovey, D
Vass, K
Walum, H
Sandnabba, K
Santtila, P
Jern, P
Westberg, L
author_sort Henningsson, S
collection PubMed
description Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two samples of younger and older individuals, respectively, with respect to one nonsynonymous polymorphism in the gene encoding the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in both samples had self-reported their sociosexual behavior using the sociosexual orientation inventory, including questions regarding lifetime number of one-night stands, number of partners last year and expected number of partners the coming 5 years. In women, there was a significant association between the VN1R1 polymorphism and sociosexual behavior in both samples, driven specifically by the question regarding one-night stands. Our results support the hypothesis that human social interaction is modulated by communication via chemosignaling.
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spelling pubmed-54167072017-05-16 A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior Henningsson, S Hovey, D Vass, K Walum, H Sandnabba, K Santtila, P Jern, P Westberg, L Transl Psychiatry Original Article Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two samples of younger and older individuals, respectively, with respect to one nonsynonymous polymorphism in the gene encoding the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in both samples had self-reported their sociosexual behavior using the sociosexual orientation inventory, including questions regarding lifetime number of one-night stands, number of partners last year and expected number of partners the coming 5 years. In women, there was a significant association between the VN1R1 polymorphism and sociosexual behavior in both samples, driven specifically by the question regarding one-night stands. Our results support the hypothesis that human social interaction is modulated by communication via chemosignaling. Nature Publishing Group 2017-04 2017-04-25 /pmc/articles/PMC5416707/ /pubmed/28440809 http://dx.doi.org/10.1038/tp.2017.70 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Henningsson, S
Hovey, D
Vass, K
Walum, H
Sandnabba, K
Santtila, P
Jern, P
Westberg, L
A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title_full A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title_fullStr A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title_full_unstemmed A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title_short A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
title_sort missense polymorphism in the putative pheromone receptor gene vn1r1 is associated with sociosexual behavior
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416707/
https://www.ncbi.nlm.nih.gov/pubmed/28440809
http://dx.doi.org/10.1038/tp.2017.70
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