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Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively

We investigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible for Schimke immuno-osseous dysplasia. Using a single-molecule magnetic tweezers assay, we construct RPA-stabilized DNA bubbles within torsionally constrained DNA to investigate the annealing act...

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Detalles Bibliográficos
Autores principales:	Burnham, Daniel R., Nijholt, Bas, De Vlaminck, Iwijn, Quan, Jinhua, Yusufzai, Timur, Dekker, Cees
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416776/ https://www.ncbi.nlm.nih.gov/pubmed/28334870 http://dx.doi.org/10.1093/nar/gkx147

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