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Ataxin-3 promotes genome integrity by stabilizing Chk1

The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, Chk1 can be targeted for proteasomal degradation to terminate checkpoint signaling after DNA repair finishes. To ensure proper activation of DNA damage checkpoint...

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Detalles Bibliográficos
Autores principales:	Tu, Yingfeng, Liu, Hongmei, Zhu, Xuefei, Shen, Hongyan, Ma, Xiaolu, Wang, Fengli, Huang, Min, Gong, Juanjuan, Li, Xiaoling, Wang, Yun, Guo, Caixia, Tang, Tie-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416811/ https://www.ncbi.nlm.nih.gov/pubmed/28180282 http://dx.doi.org/10.1093/nar/gkx095

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