Cargando…

Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo

Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the consequences of increased or decreased Pol II catalysis on gene expression in Saccharomyces cerevisiae. We find that alteration of Pol II catalytic rate, either fast or slow, leads to decreased Pol II occupancy and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malik, Indranil, Qiu, Chenxi, Snavely, Thomas, Kaplan, Craig D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416818/ https://www.ncbi.nlm.nih.gov/pubmed/28119420 http://dx.doi.org/10.1093/nar/gkx037

Ejemplares similares

SAYP and Brahma are important for ‘repressive’ and ‘transient’ Pol II pausing
por: Vorobyeva, Nadezhda E., et al.
Publicado: (2012)

The NRPD1 N-terminus contains a Pol IV-specific motif that is critical for genome surveillance in Arabidopsis
por: Ferrafiat, Laura, et al.
Publicado: (2019)

The Pol IV largest subunit CTD quantitatively affects siRNA levels guiding RNA-directed DNA methylation
por: Wendte, Jered M, et al.
Publicado: (2019)

Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD
por: Koga, Mitsunori, et al.
Publicado: (2015)

Release of promoter–proximal paused Pol II in response to histone deacetylase inhibition
por: Vaid, Roshan, et al.
Publicado: (2020)

Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis
por: Lee, Bum-Kyu, et al.
Publicado: (2011)

Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome
por: Nilson, Kyle A., et al.
Publicado: (2017)

Gcn5 facilitates Pol II progression, rather than recruitment to nucleosome-depleted stress promoters, in Schizosaccharomyces pombe
por: Sansó, Miriam, et al.
Publicado: (2011)

Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex
por: Gopalan, Sneha, et al.
Publicado: (2018)

A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation
por: Dronamraju, Raghuvar, et al.
Publicado: (2014)

RNA interference may result in unexpected phenotypes in Caenorhabditis elegans
por: De-Souza, Evandro A, et al.
Publicado: (2019)

Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover
por: Helenius, Katja, et al.
Publicado: (2011)

Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS
por: Tao, Yongguang, et al.
Publicado: (2011)

The PRP6-like splicing factor STA1 is involved in RNA-directed DNA methylation by facilitating the production of Pol V-dependent scaffold RNAs
por: Dou, Kun, et al.
Publicado: (2013)

Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1
por: Bentrari, Fatima, et al.
Publicado: (2015)

Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions
por: Hu, Gongcheng, et al.
Publicado: (2020)

Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination
por: Garg, Angad, et al.
Publicado: (2021)

Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma brucei
por: Florini, Francesca, et al.
Publicado: (2019)

TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production
por: Philippi, Anja, et al.
Publicado: (2010)

Regulatory consequences of gene translocation in bacteria
por: Block, Dena H. S., et al.
Publicado: (2012)

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding
por: Maruyama, Atsushi, et al.
Publicado: (2014)

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
por: Menendez, Daniel, et al.
Publicado: (2013)

RNA editing by T7 RNA polymerase bypasses InDel mutations causing unexpected phenotypic changes
por: Wons, Ewa, et al.
Publicado: (2015)

A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination
por: Garg, Angad, et al.
Publicado: (2020)

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli
por: Sarkar, Paramita, et al.
Publicado: (2017)

Different N-terminal isoforms of Oct-1 control expression of distinct sets of genes and their high levels in Namalwa Burkitt's lymphoma cells affect a wide range of cellular processes
por: Pankratova, Elizaveta V., et al.
Publicado: (2016)

Unexpected properties of sRNA promoters allow feedback control via regulation of a two-component system
por: Brosse, Anaïs, et al.
Publicado: (2016)

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo
por: Hirashima, Kyotaro, et al.
Publicado: (2015)

Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP–DNA dissociation
por: Heiss, Gregor, et al.
Publicado: (2019)

Autonomous actions of the human growth hormone long-range enhancer
por: Yoo, Eung Jae, et al.
Publicado: (2015)

Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary
por: Soshnev, Alexey A., et al.
Publicado: (2012)

Predicting functional consequences of SNPs on mRNA translation via machine learning
por: Li, Zheyu, et al.
Publicado: (2023)

Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome
por: Briggs, Emma, et al.
Publicado: (2018)

Explaining the disease phenotype of intergenic SNP through predicted long range regulation
por: Chen, Jingqi, et al.
Publicado: (2016)

Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
por: Onoda, Akihisa, et al.
Publicado: (2014)

High-throughput identification of long-range regulatory elements and their target promoters in the human genome
por: Hwang, Yih-Chii, et al.
Publicado: (2013)

FACT and Ash1 promote long-range and bidirectional nucleosome eviction at the HO promoter
por: Yu, Yaxin, et al.
Publicado: (2020)

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
por: Clements, Eriko G., et al.
Publicado: (2012)

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
por: Akdemir, Kadir C., et al.
Publicado: (2014)

Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers
por: Makkonen, Harri, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_bfbaovcao7lcead8becobkm9hu