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Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo

Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the consequences of increased or decreased Pol II catalysis on gene expression in Saccharomyces cerevisiae. We find that alteration of Pol II catalytic rate, either fast or slow, leads to decreased Pol II occupancy and...

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Detalles Bibliográficos
Autores principales:	Malik, Indranil, Qiu, Chenxi, Snavely, Thomas, Kaplan, Craig D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416818/ https://www.ncbi.nlm.nih.gov/pubmed/28119420 http://dx.doi.org/10.1093/nar/gkx037

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