Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice

The zinc finger protein CTCF has been invoked in establishing boundaries between genes, thereby controlling spatial and temporal enhancer activities. However, there is limited genetic evidence to support the concept that these boundaries restrict the search space of enhancers. We have addressed this...

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Detalles Bibliográficos
Autores principales: Lee, Hye Kyung, Willi, Michaela, Wang, Chaochen, Yang, Chul Min, Smith, Harold E., Liu, Chengyu, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416830/
https://www.ncbi.nlm.nih.gov/pubmed/28334928
http://dx.doi.org/10.1093/nar/gkx185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416830/
https://www.ncbi.nlm.nih.gov/pubmed/28334928
http://dx.doi.org/10.1093/nar/gkx185

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