Cargando…

Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice

The zinc finger protein CTCF has been invoked in establishing boundaries between genes, thereby controlling spatial and temporal enhancer activities. However, there is limited genetic evidence to support the concept that these boundaries restrict the search space of enhancers. We have addressed this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hye Kyung, Willi, Michaela, Wang, Chaochen, Yang, Chul Min, Smith, Harold E., Liu, Chengyu, Hennighausen, Lothar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416830/ https://www.ncbi.nlm.nih.gov/pubmed/28334928 http://dx.doi.org/10.1093/nar/gkx185

Ejemplares similares

Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation
por: Lee, Hye Kyung, et al.
Publicado: (2018)

Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation
por: Willi, Michaela, et al.
Publicado: (2016)

Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland
por: Lee, Hye Kyung, et al.
Publicado: (2021)

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome
por: Shin, Ha Youn, et al.
Publicado: (2017)

Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands
por: Lee, Hye Kyung, et al.
Publicado: (2023)

Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands
por: Hennighausen, Lothar, et al.
Publicado: (2023)

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy
por: Zeng, Xianke, et al.
Publicado: (2020)

Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
por: Willi, M., et al.
Publicado: (2017)

Simultaneous targeting of linked loci in mouse embryos using base editing
por: Lee, Hye Kyung, et al.
Publicado: (2019)

Hierarchy within the mammary STAT5-driven Wap super-enhancer
por: Shin, Ha Youn, et al.
Publicado: (2016)

Protoplasts: From Isolation to CRISPR/Cas Genome Editing Application
por: Yue, Jin-Jun, et al.
Publicado: (2021)

Base Editing in Peanut Using CRISPR/nCas9
por: Neelakandan, Anjanasree K., et al.
Publicado: (2022)

Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
por: Lee, Hye Kyung, et al.
Publicado: (2020)

Mini-Review: Transgenerational CRISPR/Cas9 Gene Editing in Plants
por: Impens, Lennert, et al.
Publicado: (2022)

Optimizing CRISPR/Cas9 Editing of Repetitive Single Nucleotide Variants
por: Usher, Inga, et al.
Publicado: (2022)

Methodologies and Challenges for CRISPR/Cas9 Mediated Genome Editing of the Mammalian Brain
por: Nishizono, Hirofumi, et al.
Publicado: (2020)

CRISPR/Cas-Based Gene Editing Strategies for DOCK8 Immunodeficiency Syndrome
por: Ravendran, Sujan, et al.
Publicado: (2022)

CRISPR/Cas genome editing improves abiotic and biotic stress tolerance of crops
por: Li, Yangyang, et al.
Publicado: (2022)

Strategies for delivery of CRISPR/Cas-mediated genome editing to obtain edited plants directly without transgene integration
por: Kocsisova, Zuzana, et al.
Publicado: (2023)

Genome Editing With TALEN, CRISPR-Cas9 and CRISPR-Cas12a in Combination With AAV6 Homology Donor Restores T Cell Function for XLP
por: Houghton, Benjamin C., et al.
Publicado: (2022)

Establishment of CRISPR/Cas9 Genome Editing in Witloof (Cichorium intybus var. foliosum)
por: De Bruyn, Charlotte, et al.
Publicado: (2020)

Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene
por: Nerys-Junior, Arildo, et al.
Publicado: (2018)

Efficient Genome Editing in Chicken DF-1 Cells Using the CRISPR/Cas9 System
por: Bai, Yichun, et al.
Publicado: (2016)

Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System
por: Meneghini, Vasco, et al.
Publicado: (2021)

Spatiotemporal Regulation of CRISPR/Cas9 Enables Efficient, Precise, and Heritable Edits in Plant Genomes
por: Rahman, Farhanur, et al.
Publicado: (2022)

Novel CRISPR/Cas applications in plants: from prime editing to chromosome engineering
por: Huang, Teng-Kuei, et al.
Publicado: (2021)

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9
por: Oh, Hyung Suk, et al.
Publicado: (2019)

Highly Efficient Genome Editing in Plant Protoplasts by Ribonucleoprotein Delivery of CRISPR-Cas12a Nucleases
por: Zhang, Yingxiao, et al.
Publicado: (2022)

CRISPR/Cas9 mediated gene editing in non-model nematode Panagrolaimus sp. PS1159
por: Hellekes, Viktoria, et al.
Publicado: (2023)

Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy
por: Atkins, Andrew, et al.
Publicado: (2021)

Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits
por: Schmidt, Jenna Kropp, et al.
Publicado: (2023)

CROTON: an automated and variant-aware deep learning framework for predicting CRISPR/Cas9 editing outcomes
por: Li, Victoria R, et al.
Publicado: (2021)

Global detection of DNA repair outcomes induced by CRISPR–Cas9
por: Liu, Mengzhu, et al.
Publicado: (2021)

Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line
por: Hellmich, Romina, et al.
Publicado: (2020)

Establishment of a genome editing tool using CRISPR-Cas9 ribonucleoprotein complexes in the non-model plant pathogen Sphaerulina musiva
por: Tannous, Joanna, et al.
Publicado: (2023)

The Application of CRISPR/Cas Systems for Antiviral Therapy
por: Baddeley, Helen J. E., et al.
Publicado: (2021)

Gene editing and scalable functional genomic screening in Leishmania species using the CRISPR/Cas9 cytosine base editor toolbox LeishBASEedit
por: Engstler, Markus, et al.
Publicado: (2023)

Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile genetic elements
por: Bernheim, Aude, et al.
Publicado: (2020)

Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
por: Fu, Ya-Wen, et al.
Publicado: (2021)

Editing efficiencies with Cas9 orthologs, Cas12a endonucleases, and temperature in rice
por: Illa-Berenguer, Eudald, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_he1qq20fc9p0bpbe1qvlgl129j