KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing

Onset of the lytic phase in the KSHV life cycle is accompanied by the rapid, global degradation of host (and viral) mRNA transcripts in a process termed host shutoff. Key to this destruction is the virally encoded alkaline exonuclease SOX. While SOX has been shown to possess an intrinsic RNase activ...

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Detalles Bibliográficos
Autores principales: Lee, Hyunah, Patschull, Anathe O.M., Bagnéris, Claire, Ryan, Hannah, Sanderson, Christopher M., Ebrahimi, Bahram, Nobeli, Irene, Barrett, Tracey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416870/
https://www.ncbi.nlm.nih.gov/pubmed/28132029
http://dx.doi.org/10.1093/nar/gkw1340

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