Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats

Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromosome fragility, and impaired repair. Specialized helicases play an important role in unwinding DNA structures to maintain genome stability. The Srs2 helicase unwinds DNA hairpins, facilitates replicati...

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Detalles Bibliográficos
Autores principales: Nguyen, Jennifer H.G., Viterbo, David, Anand, Ranjith P., Verra, Lauren, Sloan, Laura, Richard, Guy-Franck, Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416882/
https://www.ncbi.nlm.nih.gov/pubmed/28175398
http://dx.doi.org/10.1093/nar/gkx088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416882/
https://www.ncbi.nlm.nih.gov/pubmed/28175398
http://dx.doi.org/10.1093/nar/gkx088

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