Cargando…

The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)

Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many non-histone proteins, including eukaryotic elongation factor 1 alpha (eEF1A). However, the functional significance of eEF1A methylation remains obsc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Małecki, Jędrzej, Aileni, Vinay Kumar, Ho, Angela Y.Y., Schwarz, Juliane, Moen, Anders, Sørensen, Vigdis, Nilges, Benedikt S., Jakobsson, Magnus E., Leidel, Sebastian A., Falnes, Pål Ø.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416902/ https://www.ncbi.nlm.nih.gov/pubmed/28108655 http://dx.doi.org/10.1093/nar/gkx002

Ejemplares similares

Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation
por: Jakobsson, Magnus E., et al.
Publicado: (2017)

Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase
por: Jakobsson, Magnus E., et al.
Publicado: (2015)

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
por: Jakobsson, Magnus E., et al.
Publicado: (2018)

Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function
por: Małecki, Jędrzej M, et al.
Publicado: (2021)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Human seven-β-strand (METTL) methyltransferases - conquering the universe of protein lysine methylation
por: Falnes, Pål Ø., et al.
Publicado: (2023)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

A System for Enzymatic Lysine Methylation in a Desired Sequence Context
por: Aileni, Vinay Kumar, et al.
Publicado: (2017)

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
por: Klassen, Roland, et al.
Publicado: (2018)

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation
por: Ranjan, Namit, et al.
Publicado: (2021)

Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation
por: Mealey-Farr, Robert, et al.
Publicado: (2023)

RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes
por: In, Suna, et al.
Publicado: (2019)

Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer
por: Veremieva, Maryna, et al.
Publicado: (2014)

The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner
por: Samra, Nitzan, et al.
Publicado: (2015)

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
por: Knight, John RP, et al.
Publicado: (2021)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers
por: OJI, YUSUKE, et al.
Publicado: (2014)

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response
por: Vera, Maria, et al.
Publicado: (2014)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

Characterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans
por: Engelfriet, Melanie L., et al.
Publicado: (2023)

Correspondence: On the enzymology and significance of HSPA1 lysine methylation
por: Jakobsson, Magnus E., et al.
Publicado: (2016)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours
por: Tomlinson, Victoria AL, et al.
Publicado: (2005)

Neurite Outgrowth Mediated by Translation Elongation Factor eEF1A1: A Target for Antiplatelet Agent Cilostazol
por: Hashimoto, Kenji, et al.
Publicado: (2011)

Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function
por: Griffiths, Lowri A., et al.
Publicado: (2012)

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin
por: Losada, Alejandro, et al.
Publicado: (2016)

METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit
por: Wu, Qiong, et al.
Publicado: (2022)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

The Translation Elongation Factor eEF-1Bβ1 Is Involved in Cell Wall Biosynthesis and Plant Development in Arabidopsis thaliana
por: Hossain, Zakir, et al.
Publicado: (2012)

Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20
por: Houston, Lisa, et al.
Publicado: (2022)

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury
por: Romaus-Sanjurjo, Daniel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kvhvobfarjtcu32h5nungao2vd