Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair

The tumor suppressor BRCA2 is a large multifunctional protein mutated in 50–60% of familial breast cancers. BRCA2 interacts with many partners and includes multiple regions with potentially disordered structure. In homology directed DNA repair BRCA2 delivers RAD51 to DNA resulting in removal of RPA...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez, Humberto, Paul, Maarten W., Grosbart, Małgorzata, van Rossum-Fikkert, Sarah E., Lebbink, Joyce H. G., Kanaar, Roland, Houtsmuller, Adriaan B., Wyman, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416905/
https://www.ncbi.nlm.nih.gov/pubmed/28168276
http://dx.doi.org/10.1093/nar/gkx084

Ejemplares similares

Ejemplares similares