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Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia
Ictal bradycardia, which is considered to be one of the causes of sudden unexplained death in epilepsy, is rare. A 10-year-old girl with focal cortical dysplasia in her right centroparietal region developed transient ictal bradycardia during cluster seizures. Brain magnetic resonance imaging demonst...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417018/ https://www.ncbi.nlm.nih.gov/pubmed/28503592 http://dx.doi.org/10.1177/2329048X15595818 |
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author | Kimizu, Tomokazu Toshikawa, Hiromitsu Kimura, Sadami Ikeda, Tae Mogami, Yukiko Yanagihara, Keiko Kishima, Haruhiko Suzuki, Yasuhiro |
author_facet | Kimizu, Tomokazu Toshikawa, Hiromitsu Kimura, Sadami Ikeda, Tae Mogami, Yukiko Yanagihara, Keiko Kishima, Haruhiko Suzuki, Yasuhiro |
author_sort | Kimizu, Tomokazu |
collection | PubMed |
description | Ictal bradycardia, which is considered to be one of the causes of sudden unexplained death in epilepsy, is rare. A 10-year-old girl with focal cortical dysplasia in her right centroparietal region developed transient ictal bradycardia during cluster seizures. Brain magnetic resonance imaging demonstrated a high signal intensity lesion adjacent to the focal cortical dysplasia lesion. Ictal (99m)Tc-ethyl cysteinate dimer single-photon emission computed tomography (SPECT) detected hyperperfusion in an area containing the high signal intensity lesion, which was located close to the insular cortex. Since the hyperperfusion zone observed on SPECT was considered to reflect seizure propagation, it is possible that the ictal bradycardia experienced in the present case was caused by the following mechanism: The repetitive seizure activity caused the high-intensity lesion seen on MRI to expand into the right insular cortex, which controls cardiac rhythm, resulting in ictal bradycardia. |
format | Online Article Text |
id | pubmed-5417018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-54170182017-05-11 Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia Kimizu, Tomokazu Toshikawa, Hiromitsu Kimura, Sadami Ikeda, Tae Mogami, Yukiko Yanagihara, Keiko Kishima, Haruhiko Suzuki, Yasuhiro Child Neurol Open Article Ictal bradycardia, which is considered to be one of the causes of sudden unexplained death in epilepsy, is rare. A 10-year-old girl with focal cortical dysplasia in her right centroparietal region developed transient ictal bradycardia during cluster seizures. Brain magnetic resonance imaging demonstrated a high signal intensity lesion adjacent to the focal cortical dysplasia lesion. Ictal (99m)Tc-ethyl cysteinate dimer single-photon emission computed tomography (SPECT) detected hyperperfusion in an area containing the high signal intensity lesion, which was located close to the insular cortex. Since the hyperperfusion zone observed on SPECT was considered to reflect seizure propagation, it is possible that the ictal bradycardia experienced in the present case was caused by the following mechanism: The repetitive seizure activity caused the high-intensity lesion seen on MRI to expand into the right insular cortex, which controls cardiac rhythm, resulting in ictal bradycardia. SAGE Publications 2015-07-21 /pmc/articles/PMC5417018/ /pubmed/28503592 http://dx.doi.org/10.1177/2329048X15595818 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Article Kimizu, Tomokazu Toshikawa, Hiromitsu Kimura, Sadami Ikeda, Tae Mogami, Yukiko Yanagihara, Keiko Kishima, Haruhiko Suzuki, Yasuhiro Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title | Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title_full | Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title_fullStr | Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title_full_unstemmed | Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title_short | Ictal (99m)Tc-Ethyl Cysteinate Dimer SPECT Findings of a Girl With Refractory Localization-Related Epilepsy Who Developed Transient Ictal Bradycardia |
title_sort | ictal (99m)tc-ethyl cysteinate dimer spect findings of a girl with refractory localization-related epilepsy who developed transient ictal bradycardia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417018/ https://www.ncbi.nlm.nih.gov/pubmed/28503592 http://dx.doi.org/10.1177/2329048X15595818 |
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