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Dengue Virus Exposures Among Deployed U.S. Military Personnel
Dengue virus infections have adversely impacted U.S. military operations since the Spanish–American War. The erosion of mission capabilities and lost duty days are underestimated. Appreciating the incidence and prevalence of dengue infections in U.S. military personnel is important to inform disease...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Tropical Medicine and Hygiene
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417220/ https://www.ncbi.nlm.nih.gov/pubmed/28193746 http://dx.doi.org/10.4269/ajtmh.16-0663 |
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author | Hesse, Elisabeth M. Martinez, Luis J. Jarman, Richard G. Lyons, Arthur G. Eckels, Kenneth H. De La Barrera, Rafael A. Thomas, Stephen J. |
author_facet | Hesse, Elisabeth M. Martinez, Luis J. Jarman, Richard G. Lyons, Arthur G. Eckels, Kenneth H. De La Barrera, Rafael A. Thomas, Stephen J. |
author_sort | Hesse, Elisabeth M. |
collection | PubMed |
description | Dengue virus infections have adversely impacted U.S. military operations since the Spanish–American War. The erosion of mission capabilities and lost duty days are underestimated. Appreciating the incidence and prevalence of dengue infections in U.S. military personnel is important to inform disease prevention strategies. Banked pre- and post-deployment serum samples from 1,000 U.S. military personnel with a single deployment to a dengue-endemic region were tested using a screening microneutralization assay to detect anti-dengue-virus-neutralizing antibodies. A total of 76 (7.6%) post-deployment samples were positive and 15 of the pre-deployment samples were negative. These figures represent an infection incidence of 1.5% and total of 17.6 seroconversions per 10,000 deployment months. These data represent a deploying military population with a relatively high background rate of dengue seropositivity, a low level of infection during deployment compared with background infection rates in the local populations, and the potential for worsening clinical attack rates with increased frequency of deployment. Additional studies are required to more clearly elucidate the dengue infection and disease risk in U.S. military personnel. |
format | Online Article Text |
id | pubmed-5417220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-54172202017-05-08 Dengue Virus Exposures Among Deployed U.S. Military Personnel Hesse, Elisabeth M. Martinez, Luis J. Jarman, Richard G. Lyons, Arthur G. Eckels, Kenneth H. De La Barrera, Rafael A. Thomas, Stephen J. Am J Trop Med Hyg Articles Dengue virus infections have adversely impacted U.S. military operations since the Spanish–American War. The erosion of mission capabilities and lost duty days are underestimated. Appreciating the incidence and prevalence of dengue infections in U.S. military personnel is important to inform disease prevention strategies. Banked pre- and post-deployment serum samples from 1,000 U.S. military personnel with a single deployment to a dengue-endemic region were tested using a screening microneutralization assay to detect anti-dengue-virus-neutralizing antibodies. A total of 76 (7.6%) post-deployment samples were positive and 15 of the pre-deployment samples were negative. These figures represent an infection incidence of 1.5% and total of 17.6 seroconversions per 10,000 deployment months. These data represent a deploying military population with a relatively high background rate of dengue seropositivity, a low level of infection during deployment compared with background infection rates in the local populations, and the potential for worsening clinical attack rates with increased frequency of deployment. Additional studies are required to more clearly elucidate the dengue infection and disease risk in U.S. military personnel. The American Society of Tropical Medicine and Hygiene 2017-05-03 /pmc/articles/PMC5417220/ /pubmed/28193746 http://dx.doi.org/10.4269/ajtmh.16-0663 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Articles Hesse, Elisabeth M. Martinez, Luis J. Jarman, Richard G. Lyons, Arthur G. Eckels, Kenneth H. De La Barrera, Rafael A. Thomas, Stephen J. Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title | Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title_full | Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title_fullStr | Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title_full_unstemmed | Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title_short | Dengue Virus Exposures Among Deployed U.S. Military Personnel |
title_sort | dengue virus exposures among deployed u.s. military personnel |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417220/ https://www.ncbi.nlm.nih.gov/pubmed/28193746 http://dx.doi.org/10.4269/ajtmh.16-0663 |
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