Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response

Tumour hypoxia is associated with poor patient outcome and resistance to therapy. It is accompanied by widespread changes in gene expression mediated largely through the transcription factors HIF1/2/3α. Hypoxia impacts on multiple pathways throughout the cell and has widespread effects on phenotype....

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Detalles Bibliográficos
Autores principales: Memon, Danish, Dawson, Keren, Smowton, Christopher SF, Xing, Wei, Dive, Caroline, Miller, Crispin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417364/
https://www.ncbi.nlm.nih.gov/pubmed/28480052
http://dx.doi.org/10.1038/npjgenmed.2016.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417364/
https://www.ncbi.nlm.nih.gov/pubmed/28480052
http://dx.doi.org/10.1038/npjgenmed.2016.20

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