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Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response
Tumour hypoxia is associated with poor patient outcome and resistance to therapy. It is accompanied by widespread changes in gene expression mediated largely through the transcription factors HIF1/2/3α. Hypoxia impacts on multiple pathways throughout the cell and has widespread effects on phenotype....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417364/ https://www.ncbi.nlm.nih.gov/pubmed/28480052 http://dx.doi.org/10.1038/npjgenmed.2016.20 |