Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms

OBJECTIVE: Thrombin-activatable fibrinolysis inhibitor (TAFI) reduces the breakdown of fibrin clots through its action as an indirect inhibitor of plasmin. Studies in TAFI-deficient mice have implicated a potential role for TAFI in Abdominal Aortic Aneurysm (AAA) disease. The role of TAFI inhibition...

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Detalles Bibliográficos
Autores principales: Bridge, Katherine, Revill, Charlotte, Macrae, Fraser, Bailey, Marc, Yuldasheva, Nadira, Wheatcroft, Stephen, Butlin, Roger, Foster, Richard, Scott, D. Julian, Gils, Ann, Ariёns, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417566/
https://www.ncbi.nlm.nih.gov/pubmed/28472123
http://dx.doi.org/10.1371/journal.pone.0177117

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