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Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β(1) (TGF-β(1))-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells

BACKGROUND: Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. Transforming growth factor β(1) (TGF-β(1)) can induced EMT, which could increase tumor migration and invasion. Moreover, recent studies have been proven that mammalian target of rapamycin (mTOR) is a...

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Detalles Bibliográficos
Autores principales: Cheng, Ke-yan, Hao, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417590/
https://www.ncbi.nlm.nih.gov/pubmed/28446743
http://dx.doi.org/10.12659/MSM.901542