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Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity
A number of chemical compounds have been shown to induce liver tumors in mice but not in other species. While several mechanisms for this species-specific tumorigenicity have been proposed, no definitive mechanism has been established. We examined the effects of the nongenotoxic rodent hepatic carci...
Autores principales: | Coskran, Timothy M., Jiang, Zhijie, Klaunig, James E., Mager, Dixie L., Obert, Leslie, Robertson, Andrew, Tsinoremas, Nicholas, Wang, Zemin, Gosink, Mark |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417610/ https://www.ncbi.nlm.nih.gov/pubmed/28472135 http://dx.doi.org/10.1371/journal.pone.0176768 |
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