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High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess
Xanthogranulomatous pyelonephritis (XGPN) is an atypical long-term pyelonephritis with destruction of renal parenchyma and a long-term inflammatory infiltrate of macrophages. Reported presentations of transitional cell carcinoma (TCC) are different. A 73-year-old woman presented with loin pain, pros...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417617/ https://www.ncbi.nlm.nih.gov/pubmed/28491170 http://dx.doi.org/10.1016/j.radcr.2016.11.018 |
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author | Ordones, Flavio V. Das, Krishanu Prowse, Simon Cohen, Penelope Brook, Nicholas R. |
author_facet | Ordones, Flavio V. Das, Krishanu Prowse, Simon Cohen, Penelope Brook, Nicholas R. |
author_sort | Ordones, Flavio V. |
collection | PubMed |
description | Xanthogranulomatous pyelonephritis (XGPN) is an atypical long-term pyelonephritis with destruction of renal parenchyma and a long-term inflammatory infiltrate of macrophages. Reported presentations of transitional cell carcinoma (TCC) are different. A 73-year-old woman presented with loin pain, prostration, and fever. Computed tomography scan revealed poor cortical enhancement of the kidney, but some of the images bore resemblance to the characteristic “bear's paw” sign, consistent with XGPN with a 7-cm perinephric collection. She was provisionally diagnosed as severe acute pyelonephritis, possibly XGPN, with abscess. In view of the poor clinical condition, decision was made to perform nephrectomy. Histology revealed a G3pT4 high grade TCC with perineural and vascular invasion and reactive xanthogranulomatous inflammatory response. There are few reports of concomitant XGPN and TCC affecting the kidney. However, there has not been any mention of XGPN and TCC presenting as acute pyelonephritis and perinephric abscess so far. |
format | Online Article Text |
id | pubmed-5417617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54176172017-05-10 High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess Ordones, Flavio V. Das, Krishanu Prowse, Simon Cohen, Penelope Brook, Nicholas R. Radiol Case Rep Case Report Xanthogranulomatous pyelonephritis (XGPN) is an atypical long-term pyelonephritis with destruction of renal parenchyma and a long-term inflammatory infiltrate of macrophages. Reported presentations of transitional cell carcinoma (TCC) are different. A 73-year-old woman presented with loin pain, prostration, and fever. Computed tomography scan revealed poor cortical enhancement of the kidney, but some of the images bore resemblance to the characteristic “bear's paw” sign, consistent with XGPN with a 7-cm perinephric collection. She was provisionally diagnosed as severe acute pyelonephritis, possibly XGPN, with abscess. In view of the poor clinical condition, decision was made to perform nephrectomy. Histology revealed a G3pT4 high grade TCC with perineural and vascular invasion and reactive xanthogranulomatous inflammatory response. There are few reports of concomitant XGPN and TCC affecting the kidney. However, there has not been any mention of XGPN and TCC presenting as acute pyelonephritis and perinephric abscess so far. Elsevier 2017-02-03 /pmc/articles/PMC5417617/ /pubmed/28491170 http://dx.doi.org/10.1016/j.radcr.2016.11.018 Text en Crown Copyright © 2016 Published by Elsevier Inc. on behalf of under copyright license from the University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Ordones, Flavio V. Das, Krishanu Prowse, Simon Cohen, Penelope Brook, Nicholas R. High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title | High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title_full | High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title_fullStr | High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title_full_unstemmed | High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title_short | High-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
title_sort | high-grade transitional cell carcinoma masquerading as a xanthogranulomatous pyelonephritis and perinephric abscess |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417617/ https://www.ncbi.nlm.nih.gov/pubmed/28491170 http://dx.doi.org/10.1016/j.radcr.2016.11.018 |
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