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Noise-enhanced coding in phasic neuron spike trains

The stochastic nature of neuronal response has lead to conjectures about the impact of input fluctuations on the neural coding. For the most part, low pass membrane integration and spike threshold dynamics have been the primary features assumed in the transfer from synaptic input to output spiking....

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Detalles Bibliográficos
Autores principales: Ly, Cheng, Doiron, Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417623/
https://www.ncbi.nlm.nih.gov/pubmed/28472143
http://dx.doi.org/10.1371/journal.pone.0176963
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author Ly, Cheng
Doiron, Brent
author_facet Ly, Cheng
Doiron, Brent
author_sort Ly, Cheng
collection PubMed
description The stochastic nature of neuronal response has lead to conjectures about the impact of input fluctuations on the neural coding. For the most part, low pass membrane integration and spike threshold dynamics have been the primary features assumed in the transfer from synaptic input to output spiking. Phasic neurons are a common, but understudied, neuron class that are characterized by a subthreshold negative feedback that suppresses spike train responses to low frequency signals. Past work has shown that when a low frequency signal is accompanied by moderate intensity broadband noise, phasic neurons spike trains are well locked to the signal. We extend these results with a simple, reduced model of phasic activity that demonstrates that a non-Markovian spike train structure caused by the negative feedback produces a noise-enhanced coding. Further, this enhancement is sensitive to the timescales, as opposed to the intensity, of a driving signal. Reduced hazard function models show that noise-enhanced phasic codes are both novel and separate from classical stochastic resonance reported in non-phasic neurons. The general features of our theory suggest that noise-enhanced codes in excitable systems with subthreshold negative feedback are a particularly rich framework to study.
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spelling pubmed-54176232017-05-14 Noise-enhanced coding in phasic neuron spike trains Ly, Cheng Doiron, Brent PLoS One Research Article The stochastic nature of neuronal response has lead to conjectures about the impact of input fluctuations on the neural coding. For the most part, low pass membrane integration and spike threshold dynamics have been the primary features assumed in the transfer from synaptic input to output spiking. Phasic neurons are a common, but understudied, neuron class that are characterized by a subthreshold negative feedback that suppresses spike train responses to low frequency signals. Past work has shown that when a low frequency signal is accompanied by moderate intensity broadband noise, phasic neurons spike trains are well locked to the signal. We extend these results with a simple, reduced model of phasic activity that demonstrates that a non-Markovian spike train structure caused by the negative feedback produces a noise-enhanced coding. Further, this enhancement is sensitive to the timescales, as opposed to the intensity, of a driving signal. Reduced hazard function models show that noise-enhanced phasic codes are both novel and separate from classical stochastic resonance reported in non-phasic neurons. The general features of our theory suggest that noise-enhanced codes in excitable systems with subthreshold negative feedback are a particularly rich framework to study. Public Library of Science 2017-05-04 /pmc/articles/PMC5417623/ /pubmed/28472143 http://dx.doi.org/10.1371/journal.pone.0176963 Text en © 2017 Ly, Doiron http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ly, Cheng
Doiron, Brent
Noise-enhanced coding in phasic neuron spike trains
title Noise-enhanced coding in phasic neuron spike trains
title_full Noise-enhanced coding in phasic neuron spike trains
title_fullStr Noise-enhanced coding in phasic neuron spike trains
title_full_unstemmed Noise-enhanced coding in phasic neuron spike trains
title_short Noise-enhanced coding in phasic neuron spike trains
title_sort noise-enhanced coding in phasic neuron spike trains
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417623/
https://www.ncbi.nlm.nih.gov/pubmed/28472143
http://dx.doi.org/10.1371/journal.pone.0176963
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