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Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America

BACKGROUND: Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS: We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5–9 years (y) after their baseline examination in t...

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Autores principales: Pérez-Padilla, Rogelio, Fernandez-Plata, Rosario, Montes de Oca, Maria, Lopez-Varela, Maria Victorina, Jardim, Jose R., Muiño, Adriana, Valdivia, Gonzalo, Menezes, Ana Maria B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417635/
https://www.ncbi.nlm.nih.gov/pubmed/28472184
http://dx.doi.org/10.1371/journal.pone.0177032
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author Pérez-Padilla, Rogelio
Fernandez-Plata, Rosario
Montes de Oca, Maria
Lopez-Varela, Maria Victorina
Jardim, Jose R.
Muiño, Adriana
Valdivia, Gonzalo
Menezes, Ana Maria B.
author_facet Pérez-Padilla, Rogelio
Fernandez-Plata, Rosario
Montes de Oca, Maria
Lopez-Varela, Maria Victorina
Jardim, Jose R.
Muiño, Adriana
Valdivia, Gonzalo
Menezes, Ana Maria B.
author_sort Pérez-Padilla, Rogelio
collection PubMed
description BACKGROUND: Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS: We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5–9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV(1) decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. RESULTS: Expressed in ml/y, the mean annual postBD FEV(1) decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. CONCLUSIONS: Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV(1), and was higher in smokers, elderly, and women with respiratory symptoms.
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spelling pubmed-54176352017-05-14 Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America Pérez-Padilla, Rogelio Fernandez-Plata, Rosario Montes de Oca, Maria Lopez-Varela, Maria Victorina Jardim, Jose R. Muiño, Adriana Valdivia, Gonzalo Menezes, Ana Maria B. PLoS One Research Article BACKGROUND: Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS: We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5–9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV(1) decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. RESULTS: Expressed in ml/y, the mean annual postBD FEV(1) decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. CONCLUSIONS: Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV(1), and was higher in smokers, elderly, and women with respiratory symptoms. Public Library of Science 2017-05-04 /pmc/articles/PMC5417635/ /pubmed/28472184 http://dx.doi.org/10.1371/journal.pone.0177032 Text en © 2017 Pérez-Padilla et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pérez-Padilla, Rogelio
Fernandez-Plata, Rosario
Montes de Oca, Maria
Lopez-Varela, Maria Victorina
Jardim, Jose R.
Muiño, Adriana
Valdivia, Gonzalo
Menezes, Ana Maria B.
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title_full Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title_fullStr Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title_full_unstemmed Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title_short Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
title_sort lung function decline in subjects with and without copd in a population-based cohort in latin-america
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417635/
https://www.ncbi.nlm.nih.gov/pubmed/28472184
http://dx.doi.org/10.1371/journal.pone.0177032
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