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Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (J...

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Detalles Bibliográficos
Autores principales:	Bwalya, Eugene C., Kim, Sangho, Fang, Jing, Wijekoon, H. M. Suranji, Hosoya, Kenji, Okumura, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417682/ https://www.ncbi.nlm.nih.gov/pubmed/28472120 http://dx.doi.org/10.1371/journal.pone.0177144

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