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Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea

BACKGROUND/AIMS: The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic he...

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Autores principales: Baeg, Joo Yeong, Kim, In Hee, Seo, Seung Young, Kim, Young Seok, Jung, Eun Uk, Cho, Junhyeon, Chung, Jung Wha, Jang, Eun Sun, Kim, Jin Wook, Jeong, Sook-Hyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417786/
https://www.ncbi.nlm.nih.gov/pubmed/28335101
http://dx.doi.org/10.5009/gnl16242
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author Baeg, Joo Yeong
Kim, In Hee
Seo, Seung Young
Kim, Young Seok
Jung, Eun Uk
Cho, Junhyeon
Chung, Jung Wha
Jang, Eun Sun
Kim, Jin Wook
Jeong, Sook-Hyang
author_facet Baeg, Joo Yeong
Kim, In Hee
Seo, Seung Young
Kim, Young Seok
Jung, Eun Uk
Cho, Junhyeon
Chung, Jung Wha
Jang, Eun Sun
Kim, Jin Wook
Jeong, Sook-Hyang
author_sort Baeg, Joo Yeong
collection PubMed
description BACKGROUND/AIMS: The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic hepatitis C (CHC) patients. METHODS: In this prospective, multicenter study, 114 CHC patients were screened for depression using two self-reported scales, the Beck Depression Inventory-I (BDI-I) and the Hospital Anxiety and Depression scale (HADS). The incidence of depression during PR therapy was evaluated in 62 patients who underwent PR therapy during the study period. RESULTS: The prevalence of baseline depression was 17.5% according to the BDI-I score ≥10 criterion and 4.4% according to the HADS-D score ≥8 criterion in the 114 CHC patients, and it was significantly associated with an unmarried state. During PR therapy, depression developed in 34.6% according to the BDI-I scale and 29.5% according to the HADS-D, which negatively affected sustained virologic response (SVR). CONCLUSIONS: The prevalence of depression in Korean CHC patients appears to be low compared to that in Western patients; however, its incidence during PR therapy (approximately 30%) was similar to that of other populations, which led to a lower SVR rate. Active screening and multidisciplinary management of depression during PR therapy is warranted.
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spelling pubmed-54177862017-05-18 Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea Baeg, Joo Yeong Kim, In Hee Seo, Seung Young Kim, Young Seok Jung, Eun Uk Cho, Junhyeon Chung, Jung Wha Jang, Eun Sun Kim, Jin Wook Jeong, Sook-Hyang Gut Liver Original Article BACKGROUND/AIMS: The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic hepatitis C (CHC) patients. METHODS: In this prospective, multicenter study, 114 CHC patients were screened for depression using two self-reported scales, the Beck Depression Inventory-I (BDI-I) and the Hospital Anxiety and Depression scale (HADS). The incidence of depression during PR therapy was evaluated in 62 patients who underwent PR therapy during the study period. RESULTS: The prevalence of baseline depression was 17.5% according to the BDI-I score ≥10 criterion and 4.4% according to the HADS-D score ≥8 criterion in the 114 CHC patients, and it was significantly associated with an unmarried state. During PR therapy, depression developed in 34.6% according to the BDI-I scale and 29.5% according to the HADS-D, which negatively affected sustained virologic response (SVR). CONCLUSIONS: The prevalence of depression in Korean CHC patients appears to be low compared to that in Western patients; however, its incidence during PR therapy (approximately 30%) was similar to that of other populations, which led to a lower SVR rate. Active screening and multidisciplinary management of depression during PR therapy is warranted. Editorial Office of Gut and Liver 2017-05 2017-03-24 /pmc/articles/PMC5417786/ /pubmed/28335101 http://dx.doi.org/10.5009/gnl16242 Text en Copyright © 2017 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Baeg, Joo Yeong
Kim, In Hee
Seo, Seung Young
Kim, Young Seok
Jung, Eun Uk
Cho, Junhyeon
Chung, Jung Wha
Jang, Eun Sun
Kim, Jin Wook
Jeong, Sook-Hyang
Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title_full Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title_fullStr Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title_full_unstemmed Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title_short Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
title_sort prevalence and incidence of depression during interferon-based antiviral therapy in chronic hepatitis c patients in the republic of korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417786/
https://www.ncbi.nlm.nih.gov/pubmed/28335101
http://dx.doi.org/10.5009/gnl16242
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