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Nanostructure and stability of calcitonin amyloids

Calcitonin is a 32-amino acid thyroid hormone that can form amyloid fibrils. The structural basis of the fibril formation and stabilization is still debated and poorly understood. The reason is that NMR data strongly suggest antiparallel β-sheet calcitonin assembly, whereas modeling studies on the s...

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Detalles Bibliográficos
Autores principales:	Rigoldi, Federica, Metrangolo, Pierangelo, Redaelli, Alberto, Gautieri, Alfonso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418037/ https://www.ncbi.nlm.nih.gov/pubmed/28283568 http://dx.doi.org/10.1074/jbc.M116.770271

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