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Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy
The antagonistic pleiotropy (AP) theory posits that aging occurs because alleles that are detrimental in older organisms are beneficial to growth early in life and thus are maintained in populations. Although genes of the insulin signaling pathway likely participate in AP, the insulin‐regulated cell...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418193/ https://www.ncbi.nlm.nih.gov/pubmed/28185435 http://dx.doi.org/10.1111/acel.12579 |