Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents

Anthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. Possible mechanisms of ANT cardiotoxicity include their co...

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Detalles Bibliográficos
Autores principales: Piska, Kamil, Koczurkiewicz, Paulina, Bucki, Adam, Wójcik-Pszczoła, Katarzyna, Kołaczkowski, Marcin, Pękala, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418329/
https://www.ncbi.nlm.nih.gov/pubmed/28283780
http://dx.doi.org/10.1007/s10637-017-0443-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418329/
https://www.ncbi.nlm.nih.gov/pubmed/28283780
http://dx.doi.org/10.1007/s10637-017-0443-2

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