Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases

Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT(1B) receptor) and complex lesions (SERT, 5-HT(1B), 5-HT(2B) receptors) of the pulmonary vasculature together with right ventricular hypertrophy, ischemia and f...

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Detalles Bibliográficos
Autores principales: Petrassi, Mike, Barber, Rob, Be, Celine, Beach, Sarah, Cox, Brian, D’Souza, Anne-Marie, Duggan, Nick, Hussey, Martin, Fox, Roy, Hunt, Peter, Jarai, Gabor, Kosaka, Takatoshi, Oakley, Paul, Patel, Viral, Press, Neil, Rowlands, David, Scheufler, Clemens, Schmidt, Oliver, Srinivas, Honnappa, Turner, Mary, Turner, Rob, Westwick, John, Wolfreys, Alison, Pathan, Nuzhat, Watson, Simon, Thomas, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418348/
https://www.ncbi.nlm.nih.gov/pubmed/28529483
http://dx.doi.org/10.3389/fphar.2017.00240

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