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Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study

BACKGROUND: The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node...

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Autores principales: Rouzier, Roman, Uzan, Catherine, Rousseau, Alexandra, Guillot, Eugénie, Zilberman, Sonia, Meyer, Charles, Estevez, Pablo, Dupre, Pierre-Francois, Kere, David, Doridot, Virginie, D'halluin, Gauthier, Fritel, Xavier, Pouget, Nicolas, Jankowski, Clémentine, Mazouni, Chafika, Simon, Tabassome, Coutant, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418441/
https://www.ncbi.nlm.nih.gov/pubmed/28324891
http://dx.doi.org/10.1038/bjc.2017.47
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author Rouzier, Roman
Uzan, Catherine
Rousseau, Alexandra
Guillot, Eugénie
Zilberman, Sonia
Meyer, Charles
Estevez, Pablo
Dupre, Pierre-Francois
Kere, David
Doridot, Virginie
D'halluin, Gauthier
Fritel, Xavier
Pouget, Nicolas
Jankowski, Clémentine
Mazouni, Chafika
Simon, Tabassome
Coutant, Charles
author_facet Rouzier, Roman
Uzan, Catherine
Rousseau, Alexandra
Guillot, Eugénie
Zilberman, Sonia
Meyer, Charles
Estevez, Pablo
Dupre, Pierre-Francois
Kere, David
Doridot, Virginie
D'halluin, Gauthier
Fritel, Xavier
Pouget, Nicolas
Jankowski, Clémentine
Mazouni, Chafika
Simon, Tabassome
Coutant, Charles
author_sort Rouzier, Roman
collection PubMed
description BACKGROUND: The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node dissection (ALND) could be avoided. METHODS: From January 2011 to July 2012, a prospective non-interventional nationwide study was conducted (NCT01509963). We sought to identify the false reassurance rate (FRR, a negative test result is false) in patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3.5 (low risk): the proportion of patients with metastatic non-SN at additional ALND. Our hypothesis was that these patients would have a FRR⩽5%. RESULTS: Data on 2822 patients with breast cancer from 53 institutions were prospectively recorded. At least one SN was metastatic (isolated tumour cells, micro- or macrometastases) in 696 patients (24.7%). Among patients with ALND and complete data to calculate combined risk (n=504), 67 and 437 patients had low and high combined risk, respectively. Patients at low risk had less ALND (47%) compared to patients at high risk (P<0.001). This study did not meet its primary objective because the FRR in patients with low risk was 16.4% (11 out of 67) (95% confidence interval (CI): 9.7–23.1%). In the high-risk group, 33.9% (148 out of 437) (95% CI: 29.6–38.4%) had non-SN metastases (P=0.004). CONCLUSIONS: In this controlled prospective study, metastatic SN patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3.5 failed to identify patients at low risk of metastatic non-SN when completion ALND was not systematic.
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spelling pubmed-54184412018-04-25 Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study Rouzier, Roman Uzan, Catherine Rousseau, Alexandra Guillot, Eugénie Zilberman, Sonia Meyer, Charles Estevez, Pablo Dupre, Pierre-Francois Kere, David Doridot, Virginie D'halluin, Gauthier Fritel, Xavier Pouget, Nicolas Jankowski, Clémentine Mazouni, Chafika Simon, Tabassome Coutant, Charles Br J Cancer Clinical Study BACKGROUND: The purpose of this study was to prospectively evaluate the combined use of The Memorial Sloan Kettering Cancer Center nomogram and Tenon score to select, in patients with metastatic sentinel lymph node (SN), those at low risk of metastatic non-SN for whom additional axillary lymph node dissection (ALND) could be avoided. METHODS: From January 2011 to July 2012, a prospective non-interventional nationwide study was conducted (NCT01509963). We sought to identify the false reassurance rate (FRR, a negative test result is false) in patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3.5 (low risk): the proportion of patients with metastatic non-SN at additional ALND. Our hypothesis was that these patients would have a FRR⩽5%. RESULTS: Data on 2822 patients with breast cancer from 53 institutions were prospectively recorded. At least one SN was metastatic (isolated tumour cells, micro- or macrometastases) in 696 patients (24.7%). Among patients with ALND and complete data to calculate combined risk (n=504), 67 and 437 patients had low and high combined risk, respectively. Patients at low risk had less ALND (47%) compared to patients at high risk (P<0.001). This study did not meet its primary objective because the FRR in patients with low risk was 16.4% (11 out of 67) (95% confidence interval (CI): 9.7–23.1%). In the high-risk group, 33.9% (148 out of 437) (95% CI: 29.6–38.4%) had non-SN metastases (P=0.004). CONCLUSIONS: In this controlled prospective study, metastatic SN patients with both a ⩽10% probability of metastatic non-SN with the MSKCC nomogram and a Tenon score ⩽3.5 failed to identify patients at low risk of metastatic non-SN when completion ALND was not systematic. Nature Publishing Group 2017-04-25 2017-03-21 /pmc/articles/PMC5418441/ /pubmed/28324891 http://dx.doi.org/10.1038/bjc.2017.47 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Clinical Study
Rouzier, Roman
Uzan, Catherine
Rousseau, Alexandra
Guillot, Eugénie
Zilberman, Sonia
Meyer, Charles
Estevez, Pablo
Dupre, Pierre-Francois
Kere, David
Doridot, Virginie
D'halluin, Gauthier
Fritel, Xavier
Pouget, Nicolas
Jankowski, Clémentine
Mazouni, Chafika
Simon, Tabassome
Coutant, Charles
Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title_full Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title_fullStr Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title_full_unstemmed Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title_short Multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the MSKCC nomogram and the Tenon score. Results of the NOTEGS study
title_sort multicenter prospective evaluation of the reliability of the combined use of two models to predict non-sentinel lymph node status in breast cancer patients with metastatic sentinel lymph nodes: the mskcc nomogram and the tenon score. results of the notegs study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418441/
https://www.ncbi.nlm.nih.gov/pubmed/28324891
http://dx.doi.org/10.1038/bjc.2017.47
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