Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions

The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as i...

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Detalles Bibliográficos
Autores principales: Bauché, David, Marie, Julien C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418590/
https://www.ncbi.nlm.nih.gov/pubmed/28523126
http://dx.doi.org/10.1038/cti.2017.9
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author Bauché, David
Marie, Julien C
author_facet Bauché, David
Marie, Julien C
author_sort Bauché, David
collection PubMed
description The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells.
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spelling pubmed-54185902017-05-18 Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions Bauché, David Marie, Julien C Clin Transl Immunology Review The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells. Nature Publishing Group 2017-04-07 /pmc/articles/PMC5418590/ /pubmed/28523126 http://dx.doi.org/10.1038/cti.2017.9 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Review
Bauché, David
Marie, Julien C
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title_full Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title_fullStr Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title_full_unstemmed Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title_short Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
title_sort transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418590/
https://www.ncbi.nlm.nih.gov/pubmed/28523126
http://dx.doi.org/10.1038/cti.2017.9
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