A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease

Human EXOG (hEXOG) is a 5′-exonuclease that is crucial for mitochondrial DNA repair; the enzyme belongs to a nonspecific nuclease family that includes the apoptotic endonuclease EndoG. Here we report biochemical and structural studies of hEXOG, including structures in its apo form and in a complex w...

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Detalles Bibliográficos
Autores principales: Szymanski, Michal R., Yu, Wangsheng, Gmyrek, Aleksandra M., White, Mark A., Molineux, Ian J., Lee, J. Ching, Yin, Y. Whitney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418593/
https://www.ncbi.nlm.nih.gov/pubmed/28466855
http://dx.doi.org/10.1038/ncomms14959

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