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Arabidopsis proteins with a transposon-related domain act in gene silencing

Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and...

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Detalles Bibliográficos
Autores principales: Ikeda, Yoko, Pélissier, Thierry, Bourguet, Pierre, Becker, Claude, Pouch-Pélissier, Marie-Noëlle, Pogorelcnik, Romain, Weingartner, Magdalena, Weigel, Detlef, Deragon, Jean-Marc, Mathieu, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418596/
https://www.ncbi.nlm.nih.gov/pubmed/28466841
http://dx.doi.org/10.1038/ncomms15122
Descripción
Sumario:Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposon-related plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.