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The comparative immunology of wild and laboratory mice, Mus musculus domesticus

The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mic...

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Autores principales: Abolins, Stephen, King, Elizabeth C., Lazarou, Luke, Weldon, Laura, Hughes, Louise, Drescher, Paul, Raynes, John G., Hafalla, Julius C. R., Viney, Mark E., Riley, Eleanor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418598/
https://www.ncbi.nlm.nih.gov/pubmed/28466840
http://dx.doi.org/10.1038/ncomms14811
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author Abolins, Stephen
King, Elizabeth C.
Lazarou, Luke
Weldon, Laura
Hughes, Louise
Drescher, Paul
Raynes, John G.
Hafalla, Julius C. R.
Viney, Mark E.
Riley, Eleanor M.
author_facet Abolins, Stephen
King, Elizabeth C.
Lazarou, Luke
Weldon, Laura
Hughes, Louise
Drescher, Paul
Raynes, John G.
Hafalla, Julius C. R.
Viney, Mark E.
Riley, Eleanor M.
author_sort Abolins, Stephen
collection PubMed
description The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system.
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spelling pubmed-54185982017-07-06 The comparative immunology of wild and laboratory mice, Mus musculus domesticus Abolins, Stephen King, Elizabeth C. Lazarou, Luke Weldon, Laura Hughes, Louise Drescher, Paul Raynes, John G. Hafalla, Julius C. R. Viney, Mark E. Riley, Eleanor M. Nat Commun Article The laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation. Moreover, wild mice have a population of highly activated myeloid cells not present in laboratory mice. By contrast, in vitro cytokine responses to pathogen-associated ligands are generally lower in cells from wild mice, probably reflecting the importance of maintaining immune homeostasis in the face of intense antigenic challenge in the wild. These data provide a comprehensive basis for validating (or not) laboratory mice as a useful and relevant immunological model system. Nature Publishing Group 2017-05-03 /pmc/articles/PMC5418598/ /pubmed/28466840 http://dx.doi.org/10.1038/ncomms14811 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Abolins, Stephen
King, Elizabeth C.
Lazarou, Luke
Weldon, Laura
Hughes, Louise
Drescher, Paul
Raynes, John G.
Hafalla, Julius C. R.
Viney, Mark E.
Riley, Eleanor M.
The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title_full The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title_fullStr The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title_full_unstemmed The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title_short The comparative immunology of wild and laboratory mice, Mus musculus domesticus
title_sort comparative immunology of wild and laboratory mice, mus musculus domesticus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418598/
https://www.ncbi.nlm.nih.gov/pubmed/28466840
http://dx.doi.org/10.1038/ncomms14811
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