TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation

Differentiation and fate of virus-specific CD8(+) T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1(+)CD127(+)PD1(+) hepatitis C virus (HCV)-specific CD8(+) T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion a...

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Detalles Bibliográficos
Autores principales: Wieland, Dominik, Kemming, Janine, Schuch, Anita, Emmerich, Florian, Knolle, Percy, Neumann-Haefelin, Christoph, Held, Werner, Zehn, Dietmar, Hofmann, Maike, Thimme, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418623/
https://www.ncbi.nlm.nih.gov/pubmed/28466857
http://dx.doi.org/10.1038/ncomms15050

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