Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

Innate immunity plays a pivotal role in virus infection. RIG-I senses viral RNA and initiates an effective innate immune response for type I interferon production. To transduce RIG-I-mediated antiviral signalling, a mitochondrial protein MAVS forms prion-like aggregates to activate downstream kinase...

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Detalles Bibliográficos
Autores principales: Shi, Yuheng, Yuan, Bofeng, Zhu, Wenting, Zhang, Rui, Li, Lin, Hao, Xiaojing, Chen, She, Hou, Fajian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418627/
https://www.ncbi.nlm.nih.gov/pubmed/28469175
http://dx.doi.org/10.1038/ncomms15138

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