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Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

BACKGROUND: The experience from clinical trials indicates that anti-Aβ immunotherapy could be effective in early/pre-clinical stages of AD, whereas at the late stages promoting the clearing of Aβ alone may be insufficient to halt the disease progression. At the same time, pathological tau correlates...

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Detalles Bibliográficos
Autores principales:	Agadjanyan, Michael G., Zagorski, Karen, Petrushina, Irina, Davtyan, Hayk, Kazarian, Konstantin, Antonenko, Maxim, Davis, Joy, Bon, Charles, Blurton-Jones, Mathew, Cribbs, David H., Ghochikyan, Anahit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418694/ https://www.ncbi.nlm.nih.gov/pubmed/28472993 http://dx.doi.org/10.1186/s13024-017-0172-1

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