Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

BACKGROUND: Aldose reductase, the first enzyme of the polyol pathway, is the key determinant for the pathogenesis of long term diabetic complications. Accordingly, its inhibition represents the major therapeutic strategy to treat this kind of pathologies. OBJECTIVES: In this work we describe the syn...

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Detalles Bibliográficos
Autores principales: Digiacomo, Maria, Sartini, Stefania, Nesi, Giulia, Sestito, Simona, Coviello, Vito, La Motta, Concettina, Rapposelli, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418920/
https://www.ncbi.nlm.nih.gov/pubmed/28567125
http://dx.doi.org/10.2174/1874104501711010009

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