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A Review of hormone-based therapies to treat adult acne vulgaris in women

Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment...

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Autores principales: Trivedi, M.K., Shinkai, K., Murase, J.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419026/
https://www.ncbi.nlm.nih.gov/pubmed/28492054
http://dx.doi.org/10.1016/j.ijwd.2017.02.018
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author Trivedi, M.K.
Shinkai, K.
Murase, J.E.
author_facet Trivedi, M.K.
Shinkai, K.
Murase, J.E.
author_sort Trivedi, M.K.
collection PubMed
description Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted to yield 36 relevant studies for inclusion in the review and several conclusions were drawn from the literature. Treatment with oral contraceptive pills leads to significant reductions in lesion counts across all lesion types compared with placebo. There were no consistent differences in efficacy between the different combined oral contraceptive formulations. In terms of risk, oral contraceptive pill users had three-times increased odds of venous thromboembolism versus non-users according to a recent meta-analysis (95% confidence interval 2.46-2.59). Data on oral contraceptive pill use and breast cancer risk are conflicting but individual patient risk factors and histories should be discussed and considered when prescribing these medications. However, use of these medications does confer measurable protection from endometrial and ovarian cancer. Spironolactone was also shown to be an effective alternative treatment with good tolerability. Combined oral contraceptive medications and spironolactone as adjuvant and monotherapies are safe and effective to treat women with adult acne. However, appropriate clinical examinations, screening, and individual risk assessments particularly for venous thromboembolism risk must be conducted prior to initiating therapy.
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spelling pubmed-54190262017-05-10 A Review of hormone-based therapies to treat adult acne vulgaris in women Trivedi, M.K. Shinkai, K. Murase, J.E. Int J Womens Dermatol Review Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted to yield 36 relevant studies for inclusion in the review and several conclusions were drawn from the literature. Treatment with oral contraceptive pills leads to significant reductions in lesion counts across all lesion types compared with placebo. There were no consistent differences in efficacy between the different combined oral contraceptive formulations. In terms of risk, oral contraceptive pill users had three-times increased odds of venous thromboembolism versus non-users according to a recent meta-analysis (95% confidence interval 2.46-2.59). Data on oral contraceptive pill use and breast cancer risk are conflicting but individual patient risk factors and histories should be discussed and considered when prescribing these medications. However, use of these medications does confer measurable protection from endometrial and ovarian cancer. Spironolactone was also shown to be an effective alternative treatment with good tolerability. Combined oral contraceptive medications and spironolactone as adjuvant and monotherapies are safe and effective to treat women with adult acne. However, appropriate clinical examinations, screening, and individual risk assessments particularly for venous thromboembolism risk must be conducted prior to initiating therapy. Elsevier 2017-03-30 /pmc/articles/PMC5419026/ /pubmed/28492054 http://dx.doi.org/10.1016/j.ijwd.2017.02.018 Text en © 2017 Women's Dermatologic Society. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Trivedi, M.K.
Shinkai, K.
Murase, J.E.
A Review of hormone-based therapies to treat adult acne vulgaris in women
title A Review of hormone-based therapies to treat adult acne vulgaris in women
title_full A Review of hormone-based therapies to treat adult acne vulgaris in women
title_fullStr A Review of hormone-based therapies to treat adult acne vulgaris in women
title_full_unstemmed A Review of hormone-based therapies to treat adult acne vulgaris in women
title_short A Review of hormone-based therapies to treat adult acne vulgaris in women
title_sort review of hormone-based therapies to treat adult acne vulgaris in women
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419026/
https://www.ncbi.nlm.nih.gov/pubmed/28492054
http://dx.doi.org/10.1016/j.ijwd.2017.02.018
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