Cargando…

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santamaria, Salvatore, Fedorov, Oleg, McCafferty, John, Murphy, Gillian, Dudhia, Jayesh, Nagase, Hideaki, Yamamoto, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419085/ https://www.ncbi.nlm.nih.gov/pubmed/28306378 http://dx.doi.org/10.1080/19420862.2017.1304341

Ejemplares similares

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
por: Santamaria, Salvatore, et al.
Publicado: (2015)

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
por: Yamamoto, Kazuhiro, et al.
Publicado: (2016)

Inhibition of Shedding of Low‐Density Lipoprotein Receptor–Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis
por: Yamamoto, Kazuhiro, et al.
Publicado: (2017)

Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8
por: Santamaria, Salvatore, et al.
Publicado: (2021)

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
por: Troeberg, Linda, et al.
Publicado: (2012)

Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
por: Yamamoto, Kazuhiro, et al.
Publicado: (2021)

Editorial: ADAM, ADAMTS and astacin proteases: Challenges and breakthroughs in the -Omics era-Volume II
por: Kwok, Hang Fai, et al.
Publicado: (2023)

The C-terminal domains of ADAMTS1 contain exosites involved in its proteoglycanase activity
por: Minns, Alexander Frederick, et al.
Publicado: (2023)

ADAMTS proteases in cardiovascular physiology and disease
por: Santamaria, Salvatore, et al.
Publicado: (2020)

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
por: Carreca, Anna P., et al.
Publicado: (2020)

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis
por: Santamaria, Salvatore, et al.
Publicado: (2019)

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
por: Lim, Ngee H., et al.
Publicado: (2010)

The Role of ADAMTS Proteoglycanases in Thoracic Aortic Disease
por: Kemberi, Marsioleda, et al.
Publicado: (2023)

Fc-optimized monoclonal antibodies show superior efficacy
por: Flemming, Alexandra
Publicado: (2021)

Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
por: Falk, Ronny, et al.
Publicado: (2012)

Improvement of Anti-CD36 Antibody Detection via Monoclonal Antibody Immobilization of Platelet Antigens Assay by Using Selected Monoclonal Antibodies
por: Xu, Xiuzhang, et al.
Publicado: (2023)

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7
por: Colige, Alain, et al.
Publicado: (2019)

ADAMTS13 Gene Mutations in Children with Hemolytic Uremic Syndrome
por: Choi, Hyoung Soo, et al.
Publicado: (2011)

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion
por: Roberts, S., et al.
Publicado: (2015)

ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19
por: Ward, Soracha E., et al.
Publicado: (2021)

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
por: Botkjaer, Kenneth A., et al.
Publicado: (2016)

Development of a fluorogenic ADAMTS-7 substrate
por: Santamaria, Salvatore, et al.
Publicado: (2021)

A Monoclonal Antibody to the α2 Domain of Murine Major Histocompatibility Complex Class I that Specifically Kills Activated Lymphocytes and Blocks Liver Damage in the Concanavalin A Hepatitis Model
por: Matsuoka, Shuji, et al.
Publicado: (2003)

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
por: Santamaria, Salvatore, et al.
Publicado: (2021)

A Moderate Decrease in ADAMTS13 Activity Correlates with the Severity of STEC-HUS
por: Emirova, Khadizha M., et al.
Publicado: (2023)

Emphysematous Pyelonephritis: Bedside Ultrasound Diagnosis in the Emergency Department
por: McCafferty, Gillian, et al.
Publicado: (2017)

Beyond natural antibodies: the power of in vitro display technologies
por: Bradbury, Andrew R.M., et al.
Publicado: (2011)

A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13
por: Zhang, Lulu, et al.
Publicado: (2017)

Basics of Antibody Phage Display Technology
por: Ledsgaard, Line, et al.
Publicado: (2018)

The gut microbiome and the ketogenic diet: A pathway towards treatment optimization in infantile spasms
por: McCafferty, Cian
Publicado: (2022)

Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions
por: Dietert, Kristi, et al.
Publicado: (2023)

A Conformation-Sensitive Monoclonal Antibody against the A2 Domain of von Willebrand Factor Reduces Its Proteolysis by ADAMTS13
por: Zhang, Jingyu, et al.
Publicado: (2011)

Effectiveness of Monoclonal Antibodies in Preventing Severe COVID-19 With Emergence of the Delta Variant
por: O’Horo, John C., et al.
Publicado: (2022)

In-Silico Analysis of Monoclonal Antibodies against SARS-CoV-2 Omicron
por: Hu, Ye-Fan, et al.
Publicado: (2022)

Generation and Characterisation of Monoclonal Antibodies against Nairobi Sheep Disease Virus Nucleoprotein
por: Maze, Emmanuel A., et al.
Publicado: (2023)

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
por: Nikolakopoulou, Angeliki Maria, et al.
Publicado: (2021)

Arthritogenic Monoclonal Antibodies from K/BxN Mice
por: Maccioni, Mariana, et al.
Publicado: (2002)

A monoclonal antibody that blocks adhesion of Chlamydomonas mt+ gametes
Publicado: (1986)

Structural and functional characterization of a monoclonal antibody blocking TIGIT
por: Jeong, Bo-Seong, et al.
Publicado: (2022)

In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom
por: Ledsgaard, Line, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_38gd7g6c78p231rt4mq3c1vmjf