Cargando…

Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis

PURPOSE: At present, commercially available antiurolithic drugs have more adverse effects than potential therapeutic or preventive effects with chronic use. With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-indu...

Descripción completa

Detalles Bibliográficos
Autores principales: Alenzi, Mohammed, Rahiman, Shaik, Tantry, Bilal Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419107/
https://www.ncbi.nlm.nih.gov/pubmed/28480348
http://dx.doi.org/10.4111/icu.2017.58.3.210
_version_ 1783234183336820736
author Alenzi, Mohammed
Rahiman, Shaik
Tantry, Bilal Ahmad
author_facet Alenzi, Mohammed
Rahiman, Shaik
Tantry, Bilal Ahmad
author_sort Alenzi, Mohammed
collection PubMed
description PURPOSE: At present, commercially available antiurolithic drugs have more adverse effects than potential therapeutic or preventive effects with chronic use. With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis. MATERIALS AND METHODS: Adult albino mice were divided into 6 groups. Group I was fed the vehicle only. Group II was supplemented with 0.75% EG alone in drinking water during the experimental period to initiate deposition of calcium oxalate in kidneys, which leads to urolithiasis in animals. Groups III (olive oil control group) through V were fed olive oil orally at various doses during the experimental period. Group VI received cystone (750 mg/kg). Groups IV–VI additionally received 0.75% EG in drinking water ad libitum. SPSS ver.17.0 was used for statistical analysis. RESULTS: The study results showed significantly higher levels of serum urea, uric acid, and creatinine (p<0.05) in group II than in groups III–VI and I. Administration of olive oil at different doses restored the elevated serum parameters in groups IV and V compared with group II. Urine and kidney calcium, oxalate, and phosphate levels in groups IV–VI were significantly lower (p<0.05) than in animals with EG-induced urolithiasis (group II). Group V mice showed a significant restoration effect on serum as well as urine and kidney parameters compared with group II. CONCLUSIONS: Supplementation with olive oil (1.7 mL/kg body weight) reduced and prevented the growth of urinary stones, possibly by inhibiting renal tubular membrane damage due to peroxidative stress induced by hyperoxaluria.
format Online
Article
Text
id pubmed-5419107
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Korean Urological Association
record_format MEDLINE/PubMed
spelling pubmed-54191072017-05-06 Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis Alenzi, Mohammed Rahiman, Shaik Tantry, Bilal Ahmad Investig Clin Urol Original Article PURPOSE: At present, commercially available antiurolithic drugs have more adverse effects than potential therapeutic or preventive effects with chronic use. With this in mind, the present study was designed to assess the antiurolithic effect of olive oil in a mouse model of ethylene glycol (EG)-induced urolithiasis. MATERIALS AND METHODS: Adult albino mice were divided into 6 groups. Group I was fed the vehicle only. Group II was supplemented with 0.75% EG alone in drinking water during the experimental period to initiate deposition of calcium oxalate in kidneys, which leads to urolithiasis in animals. Groups III (olive oil control group) through V were fed olive oil orally at various doses during the experimental period. Group VI received cystone (750 mg/kg). Groups IV–VI additionally received 0.75% EG in drinking water ad libitum. SPSS ver.17.0 was used for statistical analysis. RESULTS: The study results showed significantly higher levels of serum urea, uric acid, and creatinine (p<0.05) in group II than in groups III–VI and I. Administration of olive oil at different doses restored the elevated serum parameters in groups IV and V compared with group II. Urine and kidney calcium, oxalate, and phosphate levels in groups IV–VI were significantly lower (p<0.05) than in animals with EG-induced urolithiasis (group II). Group V mice showed a significant restoration effect on serum as well as urine and kidney parameters compared with group II. CONCLUSIONS: Supplementation with olive oil (1.7 mL/kg body weight) reduced and prevented the growth of urinary stones, possibly by inhibiting renal tubular membrane damage due to peroxidative stress induced by hyperoxaluria. The Korean Urological Association 2017-05 2017-04-11 /pmc/articles/PMC5419107/ /pubmed/28480348 http://dx.doi.org/10.4111/icu.2017.58.3.210 Text en © The Korean Urological Association, 2017 http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alenzi, Mohammed
Rahiman, Shaik
Tantry, Bilal Ahmad
Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title_full Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title_fullStr Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title_full_unstemmed Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title_short Antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
title_sort antiurolithic effect of olive oil in a mouse model of ethylene glycol-induced urolithiasis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419107/
https://www.ncbi.nlm.nih.gov/pubmed/28480348
http://dx.doi.org/10.4111/icu.2017.58.3.210
work_keys_str_mv AT alenzimohammed antiurolithiceffectofoliveoilinamousemodelofethyleneglycolinducedurolithiasis
AT rahimanshaik antiurolithiceffectofoliveoilinamousemodelofethyleneglycolinducedurolithiasis
AT tantrybilalahmad antiurolithiceffectofoliveoilinamousemodelofethyleneglycolinducedurolithiasis