Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage

Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity,...

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Detalles Bibliográficos
Autores principales: Doni, Andrea, D'Amico, Giovanna, Morone, Diego, Mantovani, Alberto, Garlanda, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419421/
https://www.ncbi.nlm.nih.gov/pubmed/27476448
http://dx.doi.org/10.1016/j.semcdb.2016.07.026
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author Doni, Andrea
D'Amico, Giovanna
Morone, Diego
Mantovani, Alberto
Garlanda, Cecilia
author_facet Doni, Andrea
D'Amico, Giovanna
Morone, Diego
Mantovani, Alberto
Garlanda, Cecilia
author_sort Doni, Andrea
collection PubMed
description Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity, orchestrates tissue repair by interacting with plasminogen and fibrin. Fluid-phase molecules of innate immunity interact with elements of the extracellular matrix, and some of the latter display opsonic activity against certain bacterial species. Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system.
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spelling pubmed-54194212018-01-01 Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage Doni, Andrea D'Amico, Giovanna Morone, Diego Mantovani, Alberto Garlanda, Cecilia Semin Cell Dev Biol Article Innate immunity is involved in regulating inflammatory and tissue repair responses to injury. In particular, humoral innate immunity plays functions related to wound clearance from tissue debris, and regulation of macrophage and stromal cell activities. PTX3, a component of humoral innate immunity, orchestrates tissue repair by interacting with plasminogen and fibrin. Fluid-phase molecules of innate immunity interact with elements of the extracellular matrix, and some of the latter display opsonic activity against certain bacterial species. Thus, recognition of extracellular matrix and microbial components is a recurrent theme in the humoral arm of the innate immune system. Elsevier Ltd. 2017-01 2016-07-29 /pmc/articles/PMC5419421/ /pubmed/27476448 http://dx.doi.org/10.1016/j.semcdb.2016.07.026 Text en © 2016 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Doni, Andrea
D'Amico, Giovanna
Morone, Diego
Mantovani, Alberto
Garlanda, Cecilia
Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title_full Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title_fullStr Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title_full_unstemmed Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title_short Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage
title_sort humoral innate immunity at the crossroad between microbe and matrix recognition: the role of ptx3 in tissue damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419421/
https://www.ncbi.nlm.nih.gov/pubmed/27476448
http://dx.doi.org/10.1016/j.semcdb.2016.07.026
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