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Pharmacokinetic modeling of gentamicin in treatment of infective endocarditis: Model development and validation of existing models
Gentamicin shows large variations in half-life and volume of distribution (Vd) within and between individuals. Thus, monitoring and accurately predicting serum levels are required to optimize effectiveness and minimize toxicity. Currently, two population pharmacokinetic models are applied for predic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419648/ https://www.ncbi.nlm.nih.gov/pubmed/28475651 http://dx.doi.org/10.1371/journal.pone.0177324 |