SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation of true NEDD8 targets has been challenging, as overex...

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Detalles Bibliográficos
Autores principales: Coleman, Kate E, Békés, Miklós, Chapman, Jessica R, Crist, Sarah B, Jones, Mathew JK, Ueberheide, Beatrix M, Huang, Tony T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419743/
https://www.ncbi.nlm.nih.gov/pubmed/28475037
http://dx.doi.org/10.7554/eLife.24325

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