Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter...

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Detalles Bibliográficos
Autores principales: Chaptini, Cassandra, Casey, Genevieve, Harris, Adam G., Wattchow, David, Gordon, Lynne, Murrell, Dedee F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419760/
https://www.ncbi.nlm.nih.gov/pubmed/28491983
http://dx.doi.org/10.1016/j.ijwd.2015.08.002
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author Chaptini, Cassandra
Casey, Genevieve
Harris, Adam G.
Wattchow, David
Gordon, Lynne
Murrell, Dedee F.
author_facet Chaptini, Cassandra
Casey, Genevieve
Harris, Adam G.
Wattchow, David
Gordon, Lynne
Murrell, Dedee F.
author_sort Chaptini, Cassandra
collection PubMed
description We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.
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spelling pubmed-54197602017-05-10 Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa Chaptini, Cassandra Casey, Genevieve Harris, Adam G. Wattchow, David Gordon, Lynne Murrell, Dedee F. Int J Womens Dermatol Article We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement. Elsevier 2015-10-23 /pmc/articles/PMC5419760/ /pubmed/28491983 http://dx.doi.org/10.1016/j.ijwd.2015.08.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chaptini, Cassandra
Casey, Genevieve
Harris, Adam G.
Wattchow, David
Gordon, Lynne
Murrell, Dedee F.
Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title_full Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title_fullStr Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title_full_unstemmed Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title_short Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
title_sort botulinum toxin a injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419760/
https://www.ncbi.nlm.nih.gov/pubmed/28491983
http://dx.doi.org/10.1016/j.ijwd.2015.08.002
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