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Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease

The purpose of this study was to evaluate sympathetic skin response (SSR) and heart rate variability (HRV) in determining autonomic nervous system (ANS) involvement in patients with Parkinson disease (PD). Forty-eight idiopathic PD patients and 30 healthy controls participated in this study. SSR, HR...

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Autores principales: Ke, Jiang-Qiong, Shao, Sheng-Min, Zheng, Yuan-Yuan, Fu, Fang-Wang, Zheng, Guo-Qing, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419900/
https://www.ncbi.nlm.nih.gov/pubmed/28471954
http://dx.doi.org/10.1097/MD.0000000000006523
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author Ke, Jiang-Qiong
Shao, Sheng-Min
Zheng, Yuan-Yuan
Fu, Fang-Wang
Zheng, Guo-Qing
Liu, Chun-Feng
author_facet Ke, Jiang-Qiong
Shao, Sheng-Min
Zheng, Yuan-Yuan
Fu, Fang-Wang
Zheng, Guo-Qing
Liu, Chun-Feng
author_sort Ke, Jiang-Qiong
collection PubMed
description The purpose of this study was to evaluate sympathetic skin response (SSR) and heart rate variability (HRV) in determining autonomic nervous system (ANS) involvement in patients with Parkinson disease (PD). Forty-eight idiopathic PD patients and 30 healthy controls participated in this study. SSR, HRV, Unified Parkinson's Disease Rating Scale (UPDRS) III, the Scales for outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Hoehn and Yahr (H&Y) scale were evaluated. Absent lower limb SSR was determined unilaterally in 2, bilaterally in 1 of 3 advanced PD patients; there was significant difference between PD and control groups in terms of the SSR (P < 0.01), significant prolonged SSR latencies and decreased SSR amplitudes from bilateral hands and feet. Significant difference was noted in HRV between PD and control groups except for root mean square of successive differences (rMSSD) and high-frequency (HF) power (P < 0.05). There was a significant different correlation between the parameters of SSR and the SCOPA-AUT, and between the parameters (except HF power) of HRV and the SCOPA-AUT. Some parameters of SSR were relevantly associated with HRV. The right hand SSR amplitude correlated positively with the (SD) of all R-R interval, total spectral power, very low frequency. The right foot amplitude correlated positively with total spectral power. Both SSR and HRV parameters are sensitive in determining ANS dysfunction not only in late but also in the early stage of PD, which can be used for early detection of autonomic dysfunction in patients with PD and have the potential to serve as electrophysiological markers of dysautonomia of PD.
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spelling pubmed-54199002017-05-11 Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease Ke, Jiang-Qiong Shao, Sheng-Min Zheng, Yuan-Yuan Fu, Fang-Wang Zheng, Guo-Qing Liu, Chun-Feng Medicine (Baltimore) 5300 The purpose of this study was to evaluate sympathetic skin response (SSR) and heart rate variability (HRV) in determining autonomic nervous system (ANS) involvement in patients with Parkinson disease (PD). Forty-eight idiopathic PD patients and 30 healthy controls participated in this study. SSR, HRV, Unified Parkinson's Disease Rating Scale (UPDRS) III, the Scales for outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Hoehn and Yahr (H&Y) scale were evaluated. Absent lower limb SSR was determined unilaterally in 2, bilaterally in 1 of 3 advanced PD patients; there was significant difference between PD and control groups in terms of the SSR (P < 0.01), significant prolonged SSR latencies and decreased SSR amplitudes from bilateral hands and feet. Significant difference was noted in HRV between PD and control groups except for root mean square of successive differences (rMSSD) and high-frequency (HF) power (P < 0.05). There was a significant different correlation between the parameters of SSR and the SCOPA-AUT, and between the parameters (except HF power) of HRV and the SCOPA-AUT. Some parameters of SSR were relevantly associated with HRV. The right hand SSR amplitude correlated positively with the (SD) of all R-R interval, total spectral power, very low frequency. The right foot amplitude correlated positively with total spectral power. Both SSR and HRV parameters are sensitive in determining ANS dysfunction not only in late but also in the early stage of PD, which can be used for early detection of autonomic dysfunction in patients with PD and have the potential to serve as electrophysiological markers of dysautonomia of PD. Wolters Kluwer Health 2017-05-05 /pmc/articles/PMC5419900/ /pubmed/28471954 http://dx.doi.org/10.1097/MD.0000000000006523 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5300
Ke, Jiang-Qiong
Shao, Sheng-Min
Zheng, Yuan-Yuan
Fu, Fang-Wang
Zheng, Guo-Qing
Liu, Chun-Feng
Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title_full Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title_fullStr Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title_full_unstemmed Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title_short Sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with Parkinson disease
title_sort sympathetic skin response and heart rate variability in predicting autonomic disorders in patients with parkinson disease
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419900/
https://www.ncbi.nlm.nih.gov/pubmed/28471954
http://dx.doi.org/10.1097/MD.0000000000006523
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