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Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study

Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of disea...

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Autores principales: Baunbæk Egelund, Gertrud, Ertner, Gideon, Langholz Kristensen, Kristina, Vestergaard Jensen, Andreas, Benfield, Thomas L., Brandt, Christian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419909/
https://www.ncbi.nlm.nih.gov/pubmed/28471963
http://dx.doi.org/10.1097/MD.0000000000006686
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author Baunbæk Egelund, Gertrud
Ertner, Gideon
Langholz Kristensen, Kristina
Vestergaard Jensen, Andreas
Benfield, Thomas L.
Brandt, Christian T.
author_facet Baunbæk Egelund, Gertrud
Ertner, Gideon
Langholz Kristensen, Kristina
Vestergaard Jensen, Andreas
Benfield, Thomas L.
Brandt, Christian T.
author_sort Baunbæk Egelund, Gertrud
collection PubMed
description Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of diseases associated with CSF pleocytosis. CSF analyses were identified through the biochemical database used in the capital region of Denmark in the period from 2003 to 2010. In patients >15 years, clinical diagnoses associated with the finding of a CSF leukocyte count >10 × 10(6) cells/L were obtained from discharge records and patient files. A total of 1058 CSF samples from 1054 patients were included in the analysis. The median age was 50 (interquartile range: 36–67) and 53% were male. Eighty-one different diagnoses were identified in 1058 cases with an elevated CSF leukocyte count, besides unknown causes. Infections were the most common cause of CSF pleocytosis (61.4%) followed by miscellaneous causes (12.7%), vascular (9.7%), neurodegenerative (7%), neoplastic (5%), and inflammatory conditions (4.2%). Only infections presented with leukocyte counts >10,000 × 10(6)/L. Infections represented 82.6% of all cases with a leukocyte count >100 × 10(6)/L whereas 56.3% of cases with at leukocyte counts <100 × 10(6)/L were dominated by disease not related to infection. The present study may serve as a reminder to clinicians of what diseases and disease categories to suspect when patients present with CSF biochemistry indicating CNS inflammation.
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spelling pubmed-54199092017-05-11 Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study Baunbæk Egelund, Gertrud Ertner, Gideon Langholz Kristensen, Kristina Vestergaard Jensen, Andreas Benfield, Thomas L. Brandt, Christian T. Medicine (Baltimore) 5300 Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of diseases associated with CSF pleocytosis. CSF analyses were identified through the biochemical database used in the capital region of Denmark in the period from 2003 to 2010. In patients >15 years, clinical diagnoses associated with the finding of a CSF leukocyte count >10 × 10(6) cells/L were obtained from discharge records and patient files. A total of 1058 CSF samples from 1054 patients were included in the analysis. The median age was 50 (interquartile range: 36–67) and 53% were male. Eighty-one different diagnoses were identified in 1058 cases with an elevated CSF leukocyte count, besides unknown causes. Infections were the most common cause of CSF pleocytosis (61.4%) followed by miscellaneous causes (12.7%), vascular (9.7%), neurodegenerative (7%), neoplastic (5%), and inflammatory conditions (4.2%). Only infections presented with leukocyte counts >10,000 × 10(6)/L. Infections represented 82.6% of all cases with a leukocyte count >100 × 10(6)/L whereas 56.3% of cases with at leukocyte counts <100 × 10(6)/L were dominated by disease not related to infection. The present study may serve as a reminder to clinicians of what diseases and disease categories to suspect when patients present with CSF biochemistry indicating CNS inflammation. Wolters Kluwer Health 2017-05-05 /pmc/articles/PMC5419909/ /pubmed/28471963 http://dx.doi.org/10.1097/MD.0000000000006686 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5300
Baunbæk Egelund, Gertrud
Ertner, Gideon
Langholz Kristensen, Kristina
Vestergaard Jensen, Andreas
Benfield, Thomas L.
Brandt, Christian T.
Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title_full Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title_fullStr Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title_full_unstemmed Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title_short Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
title_sort cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: a retrospective cohort study
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419909/
https://www.ncbi.nlm.nih.gov/pubmed/28471963
http://dx.doi.org/10.1097/MD.0000000000006686
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