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Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study
Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of disea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419909/ https://www.ncbi.nlm.nih.gov/pubmed/28471963 http://dx.doi.org/10.1097/MD.0000000000006686 |
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author | Baunbæk Egelund, Gertrud Ertner, Gideon Langholz Kristensen, Kristina Vestergaard Jensen, Andreas Benfield, Thomas L. Brandt, Christian T. |
author_facet | Baunbæk Egelund, Gertrud Ertner, Gideon Langholz Kristensen, Kristina Vestergaard Jensen, Andreas Benfield, Thomas L. Brandt, Christian T. |
author_sort | Baunbæk Egelund, Gertrud |
collection | PubMed |
description | Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of diseases associated with CSF pleocytosis. CSF analyses were identified through the biochemical database used in the capital region of Denmark in the period from 2003 to 2010. In patients >15 years, clinical diagnoses associated with the finding of a CSF leukocyte count >10 × 10(6) cells/L were obtained from discharge records and patient files. A total of 1058 CSF samples from 1054 patients were included in the analysis. The median age was 50 (interquartile range: 36–67) and 53% were male. Eighty-one different diagnoses were identified in 1058 cases with an elevated CSF leukocyte count, besides unknown causes. Infections were the most common cause of CSF pleocytosis (61.4%) followed by miscellaneous causes (12.7%), vascular (9.7%), neurodegenerative (7%), neoplastic (5%), and inflammatory conditions (4.2%). Only infections presented with leukocyte counts >10,000 × 10(6)/L. Infections represented 82.6% of all cases with a leukocyte count >100 × 10(6)/L whereas 56.3% of cases with at leukocyte counts <100 × 10(6)/L were dominated by disease not related to infection. The present study may serve as a reminder to clinicians of what diseases and disease categories to suspect when patients present with CSF biochemistry indicating CNS inflammation. |
format | Online Article Text |
id | pubmed-5419909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-54199092017-05-11 Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study Baunbæk Egelund, Gertrud Ertner, Gideon Langholz Kristensen, Kristina Vestergaard Jensen, Andreas Benfield, Thomas L. Brandt, Christian T. Medicine (Baltimore) 5300 Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS. The present study investigated the variety of diseases associated with CSF pleocytosis. CSF analyses were identified through the biochemical database used in the capital region of Denmark in the period from 2003 to 2010. In patients >15 years, clinical diagnoses associated with the finding of a CSF leukocyte count >10 × 10(6) cells/L were obtained from discharge records and patient files. A total of 1058 CSF samples from 1054 patients were included in the analysis. The median age was 50 (interquartile range: 36–67) and 53% were male. Eighty-one different diagnoses were identified in 1058 cases with an elevated CSF leukocyte count, besides unknown causes. Infections were the most common cause of CSF pleocytosis (61.4%) followed by miscellaneous causes (12.7%), vascular (9.7%), neurodegenerative (7%), neoplastic (5%), and inflammatory conditions (4.2%). Only infections presented with leukocyte counts >10,000 × 10(6)/L. Infections represented 82.6% of all cases with a leukocyte count >100 × 10(6)/L whereas 56.3% of cases with at leukocyte counts <100 × 10(6)/L were dominated by disease not related to infection. The present study may serve as a reminder to clinicians of what diseases and disease categories to suspect when patients present with CSF biochemistry indicating CNS inflammation. Wolters Kluwer Health 2017-05-05 /pmc/articles/PMC5419909/ /pubmed/28471963 http://dx.doi.org/10.1097/MD.0000000000006686 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5300 Baunbæk Egelund, Gertrud Ertner, Gideon Langholz Kristensen, Kristina Vestergaard Jensen, Andreas Benfield, Thomas L. Brandt, Christian T. Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title | Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title_full | Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title_fullStr | Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title_full_unstemmed | Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title_short | Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study |
title_sort | cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: a retrospective cohort study |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419909/ https://www.ncbi.nlm.nih.gov/pubmed/28471963 http://dx.doi.org/10.1097/MD.0000000000006686 |
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