Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides

[Image: see text] The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one...

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Detalles Bibliográficos
Autores principales: Roiser, Lukas, Waser, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420312/
https://www.ncbi.nlm.nih.gov/pubmed/28425286
http://dx.doi.org/10.1021/acs.orglett.7b00869
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author Roiser, Lukas
Waser, Mario
author_facet Roiser, Lukas
Waser, Mario
author_sort Roiser, Lukas
collection PubMed
description [Image: see text] The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules.
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spelling pubmed-54203122017-05-06 Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides Roiser, Lukas Waser, Mario Org Lett [Image: see text] The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules. American Chemical Society 2017-04-20 2017-05-05 /pmc/articles/PMC5420312/ /pubmed/28425286 http://dx.doi.org/10.1021/acs.orglett.7b00869 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Roiser, Lukas
Waser, Mario
Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title_full Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title_fullStr Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title_full_unstemmed Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title_short Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
title_sort enantioselective spirocyclopropanation of para-quinone methides using ammonium ylides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420312/
https://www.ncbi.nlm.nih.gov/pubmed/28425286
http://dx.doi.org/10.1021/acs.orglett.7b00869
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